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LncRNA polymorphisms and breast cancer risk
Esmat Abdi1, Saeid Latifi-Navid1, Hamid Latifi-Navid2
1Department of Biology, Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil 5619911367 Iran.
Pathology, Research and Practice
|December 24, 2021
Summary
Long non-coding RNA (lncRNA) polymorphisms may influence breast cancer (BC) risk. Genetic variations in lncRNAs could help predict BC development and patient outcomes, aiding early detection and personalized treatment strategies.
Area of Science:
- Genetics
- Molecular Biology
- Oncology
Background:
- Breast cancer (BC) is a leading cause of cancer mortality in women globally.
- BC development involves complex interactions of genetic, lifestyle, and environmental factors.
- Long non-coding RNAs (lncRNAs) are increasingly recognized for their roles in cancer, including BC.
Purpose of the Study:
- To investigate the association between long non-coding RNA (lncRNA) polymorphisms and breast cancer (BC) risk.
- To determine if lncRNA variants can predict BC incidence and clinical outcomes.
Main Methods:
- The study examined single-nucleotide polymorphisms (SNPs) within lncRNAs.
- Genotyping of lncRNA-related variants was performed.
- Statistical analyses were conducted to assess the relationship between genotypes and BC risk.
Main Results:
- lncRNA polymorphisms were found to be associated with breast cancer (BC) risk.
- Specific individual and combined genotypes of lncRNA variants showed predictive value for BC.
- These genetic variations may influence susceptibility to BC and affect patient outcomes.
Conclusions:
- lncRNA polymorphisms represent potential biomarkers for breast cancer (BC) risk assessment.
- Further large-scale studies across diverse ethnic groups are needed for validation.
- Functional studies are essential to elucidate the etiological role of lncRNA variants in BC.
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