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Updated: Oct 8, 2025
Nanosensors to Detect Protease Activity In Vivo for Noninvasive Diagnostics
Published on: July 16, 2018
Multiple fluorescence quenching effects mediated fluorescent sensing of captopril Based on amino Acids-Derivative
Qi Wang1, Ziru Zhang1, Tian Yang1
1Chemistry & Chemical Engineering Department, Department of Environment and Safety Engineering, Department of Materials Engineering, Taiyuan Institute of Technology, Taiyuan 030008, PR China.
Abstract:
Carbon nanodots (CNDs) were facilely synthesized through a pyrolysis procedure with histamine, an amino acid rich in element carbon and nitrogen, being the precursor. Taking advantage of the favorable fluorescence performance of CNDs, a multiple fluorescence quenching effects mediated fluorescent sensor was established for captopril (CAP) detection. MnO2 NPs were firstly combined with CNDs via electrostatic attraction and subsequently quenched the fluorescence. The quenching mechanisms were concluded to be the combined effects of fluorescence resonance energy transfer (FRET) and inner filtration effect (IFE). Subsequently CAP triggered a unique redox reaction and decomposed the quencher so that renewed the fluorescence. Hence, the sensitive and selective detection of CAP was achieved through the indication of fluorescence recovery efficiency. A proportional range of 0.4 ∼ 60 μmol L-1 with the LOD of 0.31 μmol L-1 was obtained. The sensor was further applied to the real sample detection and the satisfactory results revealed the practical value of CNDs. The facile synthesis of CNDs and brand-new sensing mechanism made it a novel fluorescent method and could improve the analysis of CAP.
