Related Experiment Video

Updated: Oct 8, 2025

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.4K

Aortic stenosis in chronic kidney disease: challenges in diagnosis and treatment

Jessica I Gupta1,2, Sarah K Gualano3,2, Nicole Bhave3,2

  • 1Internal Medicine, Division of Cardiology, Ann Arbor VA Medical Center, Ann Arbor, Michigan, USA jparsh@med.umich.edu.

Heart (British Cardiac Society)
|December 25, 2021
PubMed

Insights

Chronic kidney disease (CKD) complicates aortic stenosis (AS) diagnosis and management, increasing mortality risk. A heart-kidney multidisciplinary team is crucial for optimal patient care.

Area of Science:

  • Cardiology
  • Nephrology
  • Medical Imaging

Background:

  • Chronic kidney disease (CKD) is a growing public health concern.
  • CKD is linked to the development and accelerated progression of aortic stenosis (AS).
  • Patients with both AS and CKD exhibit significantly higher mortality rates compared to those with AS and normal kidney function.

Purpose of the Study:

  • To highlight the diagnostic challenges of severe AS in CKD patients.
  • To discuss management complexities and treatment options for severe AS in CKD.
  • To emphasize the importance of a multidisciplinary approach.

Main Methods:

  • Review of current literature on AS and CKD.
  • Analysis of diagnostic challenges due to altered hemodynamics and cardiac structure in CKD.
  • Evaluation of treatment strategies including bioprosthetic and mechanical valve replacement.

Main Results:

  • Diagnosis of severe AS in CKD is often difficult, requiring multimodal imaging.
  • CKD patients face increased risks with valve replacement, including bioprosthetic structural deterioration and bleeding.
  • Higher competing risks of mortality associated with CKD itself.

Conclusions:

  • Aortic valve replacement is the definitive treatment for severe AS.
  • Management of AS in CKD patients is complex due to competing risks and treatment complications.
  • A heart-kidney multidisciplinary team is essential for optimal diagnosis and management decisions in patients with CKD and severe AS.

Keywords:
aortic valve stenosiscardiac imaging techniquescomputed tomography angiographyechocardiographyheart valve prosthesis

More Related Videos

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

929
A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis08:21

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis

Published on: October 26, 2020

5.1K

Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
110
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
100
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
77
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
140
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
78
Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
65