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Updated: Oct 8, 2025

Pupillary Response as Assessment of Effective Seizure Induction by Electroconvulsive Therapy
Published on: April 11, 2019
Serial case report of high seizure threshold patients that responded to the lengthening of pulse width in ECT
Hiroshi Katagai1, Norio Yasui-Furukori2, Hirotsugu Kawashima3
1Department of Neuropsychiatry, Hirosaki-Aiseikai Hospital, Hirosaki, Japan.
Abstract:
Electroconvulsive therapy (ECT) has been used as an effective treatment modality for psychiatric disorders. In patients with high seizure thresholds, augmentation strategies are considered such as changing anesthetic agents, hyperventilation, and premedication with theophylline. We tried to switch to "long (1.5 ms)" brief pulse ECT in all six patients from October 2020. The successful induction of effective seizures with "long" brief pulse stimulation in five of six patients who could not be treated adequately with standard ECT. In the current situation in cases in which brief pulse ECT, with the maximum dose did not lead to effective seizures, "long" brief pulse waves may be a promising option.
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