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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
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The human larynx, often referred to as the voice box, is an intricate organ located in the neck. It serves as a pathway for air to enter the lungs during respiration and is an essential component of voice production.
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Learning Modern Laryngeal Surgery in a Dissection Laboratory
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Radiotherapy for laryngeal cancers.

J Biau1, Y Pointreau2, P Blanchard3

  • 1Département de radiothérapie, centre Jean-Perrin, 58, rue Montalembert, BP 5026, 63011 Clermont-Ferrand cedex 1, France.

Cancer Radiotherapie : Journal De La Societe Francaise De Radiotherapie Oncologique
|December 26, 2021
PubMed
Summary

French oncological radiotherapy guidelines recommend intensity modulated radiotherapy for laryngeal cancers. Organ preservation strategies and specific treatment pathways for early and advanced stages are detailed.

Keywords:
DelineationDoseDosesDélinéationIndicationIndicationsIntensity-modulated radiotherapyLarynx cancerRadiothérapie conformationnelle avec modulation d’intensitéRecommandationsRecommendationsSociété française de radiothérapie oncologiqueTumeurs laryngée

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Area of Science:

  • Oncology
  • Radiotherapy
  • Head and Neck Cancer

Background:

  • Laryngeal cancer treatment requires updated guidelines for optimal patient outcomes.
  • Intensity modulated radiotherapy (IMRT) is established as a standard for laryngeal cancer management.

Purpose of the Study:

  • To present updated French Society of Oncological Radiotherapy recommendations for laryngeal cancer radiotherapy.
  • To outline treatment strategies based on tumor stage and organ preservation goals.

Main Methods:

  • Review and synthesis of current evidence and clinical practice for laryngeal cancer radiotherapy.
  • Development of consensus-based recommendations for definitive and postoperative radiotherapy.

Main Results:

  • IMRT is the standard of care for laryngeal cancers.
  • Early-stage (T1-T2) tumors offer radiotherapy or conservative surgery options.
  • Organ preservation strategies (induction chemotherapy + radiotherapy or chemoradiotherapy) are recommended for T2-T3 tumors requiring laryngectomy.
  • Total laryngectomy followed by radiotherapy is recommended for T4 tumors when feasible.

Conclusions:

  • Updated recommendations provide a clear framework for laryngeal cancer radiotherapy.
  • Treatment decisions should be individualized based on tumor stage, patient factors, and organ preservation goals.
  • Detailed guidance on dose regimens and target volume delineation is provided.