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Related Concept Videos

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Related Experiment Video

Updated: Oct 8, 2025

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma
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Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma

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Hepatic tumours and radiotherapy.

E Rio1, F Mornex2, P Maingon3

  • 1Service de radiothérapie, institut de cancérologie de l'Ouest, boulevard Jacques-Monod, 44805 Saint-Herblain, France.

Cancer Radiotherapie : Journal De La Societe Francaise De Radiotherapie Oncologique
|December 26, 2021
PubMed
Summary
This summary is machine-generated.

Updated French recommendations for focused liver radiation therapy emphasize tailored techniques for primary and secondary hepatic tumors. Stereotactic body radiotherapy is often preferred for smaller tumors, with adaptations for larger hepatocellular carcinomas.

Keywords:
Carcinome hépatocellulaireFoieFrench society for radiation oncologyGuidelinesHepatocellular carcinomaLiverLiver metastasisMétastases hépatiquesRadiation therapyRadiothérapieRadiothérapie en conditions stéréotaxiquesRecommandationsSociété française de radiothérapie oncologiqueStereotactic radiotherapy

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Area of Science:

  • Oncological Radiotherapy
  • Hepatobiliary Malignancies

Background:

  • Technological advancements have enabled focused liver radiation therapy.
  • Distinguishing between primary and secondary hepatic tumors is crucial for treatment indications.

Purpose of the Study:

  • To update recommendations for hepatic tumor radiotherapy.
  • To outline indications and techniques for focused liver radiation therapy.

Main Methods:

  • Dose fractionation and irradiation techniques are determined by tumor volume and proximity to organs at risk.
  • Tumor and liver motion, particularly breathing-related, must be accounted for.
  • Strict dosimetric criteria and dose-volume histograms are essential, especially for hypofractionated radiotherapy.

Main Results:

  • Stereotactic body radiotherapy is increasingly preferred over radiofrequency ablation for tumors under 5cm.
  • Adapted conformal fractionated irradiation protocols, potentially with intensity modulation, are suitable for hepatocellular carcinomas larger than 5cm.

Conclusions:

  • Focused liver radiation therapy offers an alternative to surgery or medical treatments for hepatic tumors.
  • Personalized treatment planning considering tumor characteristics and critical organ constraints is paramount for effective radiotherapy.