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Radiotherapy for penile cancers.

A Escande1, D Peiffert2, C Dejean3

  • 1Département de radiothérapie, centre Oscar-Lambret, 3, avenue Frédéric-Combemale, 59000 Lille, France; Faculté de médecine Henri-Warembourg, université de Lille, 59000 Lille, France; Laboratoire Cristal, UMR 9189, 59009 Villeneuve-d'Ascq, France.

Cancer Radiotherapie : Journal De La Societe Francaise De Radiotherapie Oncologique
|December 26, 2021
PubMed
Summary
This summary is machine-generated.

Radiotherapy, including brachytherapy and external beam radiation therapy, offers excellent outcomes for early-stage penile glans cancer, aiding disease control and organ preservation. Evidence for external beam radiation therapy in lymph node management is limited, requiring individualized treatment decisions.

Keywords:
BrachytherapyCancer de vergeCancer du pénisCuriethérapieFrench society for radiation oncologyGlans cancerGuidelinesPenile cancerRadiation oncologyRadiotherapyRadiothérapieRecommandationsSociété française de radiothérapie oncologique

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Area of Science:

  • Oncology
  • Radiation Oncology
  • Urologic Oncology

Background:

  • Penile cancers are rare malignancies requiring specialized treatment centers.
  • Current radiotherapy indications primarily focus on brachytherapy for early-stage glans cancer.
  • Limited data exist for external beam radiation therapy (EBRT) in penile cancer management.

Purpose of the Study:

  • To present French Society of Oncological Radiotherapy (FSOR) recommendations for penile glans cancer radiotherapy.
  • To outline indications and techniques for both external beam radiation therapy and brachytherapy.
  • To clarify the role of EBRT in palliative and lymph node management.

Main Methods:

  • Review of existing literature and clinical expertise.
  • Development of evidence-based guidelines for radiotherapy in penile cancer.
  • Focus on brachytherapy for early-stage disease and EBRT for palliative and nodal indications.

Main Results:

  • Brachytherapy demonstrates excellent disease control and organ preservation for early-stage penile glans cancer.
  • EBRT may be considered for palliative treatment of the primary tumor.
  • EBRT (with or without chemotherapy) can be explored as neoadjuvant or adjuvant therapy for lymph node irradiation in select cases, though evidence is limited.

Conclusions:

  • Radiotherapy, particularly brachytherapy, is crucial for managing early-stage penile glans cancer.
  • The use of EBRT for penile cancer requires careful consideration due to limited evidence, especially for lymph node management.
  • Individualized treatment planning is essential for patients undergoing radiotherapy for penile cancer.