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Updated: Oct 8, 2025

Quantitative 3D Imaging of Trypanosoma cruzi-Infected Cells, Dormant Amastigotes, and T Cells in Intact Clarified Organs
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Quantitative 3D Imaging of Trypanosoma cruzi-Infected Cells, Dormant Amastigotes, and T Cells in Intact Clarified Organs

Published on: June 23, 2022

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SOCS2 expression in hematopoietic and non-hematopoietic cells during Trypanosoma cruzi infection: Correlation with

Paulo Gaio1, Melisa Gualdrón-López2, Allysson Cramer1

  • 1Department of Biochemistry and Immunology, Institute of Biological Science, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Clinical Immunology (Orlando, Fla.)
|December 26, 2021
PubMed

Insights

Suppressor of cytokine signaling 2 (SOCS2) deficiency impairs immune responses to Chagas disease. SOCS2 loss in mice led to cardiac dysfunction, suggesting a link between SOCS2 and Chagasic cardiomyopathy susceptibility.

Area of Science:

  • Immunology
  • Parasitology
  • Molecular Biology

Background:

  • Chagas disease pathogenesis involves complex host immune responses.
  • Suppressor of cytokine signaling 2 (SOCS2) is vital for regulating cytokine production.

Purpose of the Study:

  • To investigate the role of SOCS2 in the immune response to Trypanosoma cruzi infection.
  • To determine the impact of SOCS2 deficiency on Chagas disease development and cardiomyopathy.

Main Methods:

  • Studied SOCS2-deficient mice and chimeric mice with SOCS2 knockout bone marrow transplantation.
  • Analyzed immune cell populations (neutrophils, dendritic cells, macrophages, T cells) and lymphocyte apoptosis.
  • Performed electrocardiogram analysis to assess cardiac function.

Main Results:

  • SOCS2 deficiency caused initial immune cell imbalance, affecting neutrophils and dendritic cells.
  • Reduced inflammatory and regulatory immune cells, increased lymphocyte apoptosis in SOCS2-deficient mice.
  • SOCS2 knockout bone marrow transplantation into wild-type mice exacerbated heart dysfunction.

Conclusions:

  • SOCS2 is a critical regulator of the immune response during Trypanosoma cruzi infection.
  • SOCS2 genetic variations may increase susceptibility to Chagasic cardiomyopathy.
Keywords:
Cardiac functionChagas diseaseImmunorregulationSOCS2Trypanosoma cruzi

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