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Achieving Adjustable Multifunction Based on Host-Guest Interaction-Manipulated Reversible Molecular Conformational

Dong Li1, Yujie Han1, Yanrong Jiang2

  • 1Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, P. R. China.

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Summary

This study introduces a novel molecular switch that changes shape using host-guest interactions, avoiding byproduct formation. This molecular switch offers reversible conformational changes with visual feedback for sensing applications.

Keywords:
conformational switchingcyclodextrinfluorescencehost−guest chemistrythermosensing

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Area of Science:

  • Supramolecular Chemistry
  • Molecular Engineering
  • Materials Science

Background:

  • Small molecules with tunable conformations are crucial for molecular switches and sensors.
  • Existing methods for controlling molecular conformation often involve irreversible processes, leading to byproducts and material fatigue.

Purpose of the Study:

  • To develop a molecular system for reversible conformational switching using host-guest interactions.
  • To create a molecule whose conformational states can be visualized and utilized for sensing applications.
  • To explore the relationship between molecular conformation and function, particularly in sensing.

Main Methods:

  • Utilizing host-guest complexation between a specific molecule and rigid macrocycles to control conformational states (stretched vs. folded).
  • Incorporating luminous properties for real-time visualization and identification of conformational states.
  • Investigating the molecule's performance in applications such as multicolor emission and ratiometric fluorescent thermosensing.

Main Results:

  • Demonstrated precise control over molecular conformation between stretched and folded states via host-guest interactions.
  • Achieved byproduct-free and fatigue-free conformational switching with excellent reversibility.
  • Developed a self-reporting system with luminous readout for real-time monitoring of conformational states.
  • Showcased applications including controllable multicolor emission, ratiometric fluorescent thermosensing with tunable detection ranges, and intracellular temperature imaging.

Conclusions:

  • The developed host-guest system provides a robust platform for reversible molecular switches and sensors.
  • The molecule's conformational control enables diverse functionalities, including advanced thermosensing and real-time biological imaging.
  • This work highlights the potential of single-molecule conformational dynamics for developing sophisticated functional materials.