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Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

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External radiotherapy for prostatic cancers.

R de Crevoisier1, S Supiot2, G Créhange3

  • 1Département de radiothérapie, Centre régional de lutte contre le cancer Eugène-Marquis, 35042 Rennes, France.

Cancer Radiotherapie : Journal De La Societe Francaise De Radiotherapie Oncologique
|December 27, 2021
PubMed
Summary
This summary is machine-generated.

Updated French guidelines recommend advanced external radiotherapy techniques for prostate cancer, including intensity-modulated radiotherapy and hypofractionation. These methods offer effective treatment for localized and oligometastatic disease, with detailed protocols for various fractionation schedules.

Keywords:
Cancer de la prostateFrench society for radiation oncologyGuidelinesProstate cancerRadiation therapyRadiothérapieRecommandationsSociété française de radiothérapie oncologique

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Area of Science:

  • Oncological Radiotherapy
  • Radiation Oncology
  • Urologic Oncology

Background:

  • External radiotherapy is a primary treatment for localized prostate cancer.
  • Recent advancements extend its use to oligometastatic prostate cancer.
  • Updated recommendations are crucial for optimizing patient care.

Purpose of the Study:

  • To present the updated recommendations from the French Society of Oncological Radiotherapy.
  • To detail current external radiotherapy techniques for prostate cancer.
  • To provide guidance on fractionation and dose escalation strategies.

Main Methods:

  • Intensity-modulated radiotherapy (IMRT) combined with image-guided radiotherapy (IGRT) is the recommended technique.
  • Standard fractionation involves 74–80Gy in 2Gy fractions.
  • Moderate hypofractionation (60Gy in 3Gy fractions over 4 weeks) is a standard option.
  • Extreme hypofractionation (35–40Gy in five fractions) using stereotactic body radiotherapy (SBRT) is an option for prostate-only treatment.
  • Simultaneous integrated boost (SIB) techniques for lymph node areas are described.
  • Postoperative irradiation techniques for recurrence and lymph node involvement are detailed.

Main Results:

  • IMRT with IGRT is the preferred method for external beam radiation therapy.
  • Various fractionation schedules, including moderate and extreme hypofractionation, are validated therapeutic options.
  • SIB allows for targeted dose escalation to lymph node regions.
  • Specific techniques for postoperative radiotherapy are outlined.

Conclusions:

  • The updated recommendations emphasize advanced radiotherapy techniques for prostate cancer management.
  • Hypofractionation, particularly moderate hypofractionation, is established as a standard treatment.
  • SBRT offers a highly hypofractionated option for select cases.
  • Comprehensive guidelines cover primary, adjuvant, and re-irradiation scenarios.