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[Intracameral penetration of pefloxacine in man]
Journal Francais D'Ophtalmologie
|January 1, 1986
Abstract:
Authors have studied the intraocular penetration of a new antibiotic, pefloxacin in 35 patients (35 eyes). This study emphasizes the three main qualities of this recent quinolone in ophthalmology: wide spectrum adequate for the most pathogens commonly found in endophthalmitis. Very large penetration in the aqueous humour flow with an average level of 0.95 mu/ml, which is over the minimal inhibitory concentration for many bacterial infections and is equal to 25% of average serum level.
Insights
Pefloxacin, a new quinolone antibiotic, shows excellent intraocular penetration for treating eye infections. Its high concentration in aqueous humor exceeds minimal inhibitory levels for common pathogens.
Area of Science:
- Ophthalmology
- Pharmacology
- Microbiology
Context:
- Endophthalmitis is a severe intraocular infection requiring effective antibiotic treatment.
- Limited intraocular penetration can reduce the efficacy of systemic antibiotics.
- Pefloxacin represents a novel quinolone antibiotic for ophthalmic applications.
Purpose:
- To evaluate the intraocular penetration and concentration of pefloxacin in the aqueous humor.
- To assess the potential of pefloxacin as a treatment for bacterial endophthalmitis.
Summary:
- This study investigated the intraocular penetration of pefloxacin in 35 patients.
- Pefloxacin demonstrated significant penetration into the aqueous humor, reaching an average concentration of 0.95 mu/ml.
- This concentration is above the minimal inhibitory level for many common bacterial pathogens and represents 25% of average serum levels.
Impact:
- Pefloxacin exhibits promising characteristics for treating intraocular infections due to its wide spectrum and excellent penetration.
- The findings support the potential use of pefloxacin in managing bacterial endophthalmitis.
- Further research may establish pefloxacin as a key therapeutic agent in ophthalmic infectious disease.