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Total Flavonoids of Chuju Decrease Oxidative Stress and Cell Apoptosis in Ischemic Stroke Rats: Network and

Cong Wang1, Hao Chen1, Hui-Hui Jiang2

  • 1College of Life and Health Sciences, Anhui Science and Technology University, Chuzhou, China.

Frontiers in Neuroscience
|December 27, 2021
PubMed
Summary
This summary is machine-generated.

Total flavonoids of Chuju (TFCJ) show neuroprotective effects against ischemic stroke (IS) in rats. TFCJ alleviates brain damage by reducing apoptosis and oxidative stress via the PI3K/Akt/mTOR pathway.

Keywords:
MCAOPI3K/Akt/mTORapoptosisischemic strokenetwork pharmacologyoxidative stresstotal flavonoids of Chuju

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Traditional Chinese Medicine

Background:

  • Total flavonoids of Chuju (TFCJ) are known to treat myocardial ischemia.
  • This study investigates the neuroprotective potential of TFCJ in a rat model of ischemic stroke (IS).

Purpose of the Study:

  • To evaluate the efficacy of TFCJ in mitigating ischemic stroke-induced brain damage.
  • To elucidate the underlying mechanisms, focusing on apoptosis, oxidative stress, and the PI3K/Akt/mTOR signaling pathway.

Main Methods:

  • TFCJ administered to rats subjected to middle cerebral artery occlusion (MCAO) and reperfusion.
  • Assessment of neurological deficits, oxidative stress markers, and pathomorphological changes.
  • Network pharmacology and Western blot analysis to investigate the PI3K/Akt/mTOR pathway and apoptosis-related proteins.

Main Results:

  • TFCJ treatment significantly reduced MCAO-induced brain damage and improved neurobehavioral functions.
  • TFCJ alleviated cell apoptosis and oxidative stress in MCAO rats.
  • TFCJ upregulated p-AKT and p-mTOR levels, effects reversed by a PI3K inhibitor, confirming pathway involvement.

Conclusions:

  • TFCJ demonstrates significant neuroprotective effects against ischemic stroke in rats.
  • The protective mechanism involves the suppression of apoptosis and oxidative stress through the PI3K/Akt/mTOR signaling pathway.
  • TFCJ is a promising traditional Chinese medicine for managing ischemic stroke.