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Updated: Oct 8, 2025

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex

Published on: September 5, 2018

Cortical Cartography: Mapping Arealization Using Single-Cell Omics Technology.

Patricia R Nano¹, Claudia V Nguyen¹, Jessenya Mil¹

¹Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, United States.

Frontiers in Neural Circuits

|December 27, 2021

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This summary is machine-generated.

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Understanding the human cerebral cortex requires studying its specialized areas. New multi-omic single-cell approaches promise deeper insights into cortical development and function.

Area of Science:

Neuroscience
Developmental Biology
Genomics

Background:

The cerebral cortex's modular network is crucial for cognition, behavior, and perception.
Disruptions in cortical area organization are linked to neurodevelopmental and psychiatric disorders.
Studying human cortical development is challenging due to the lack of tractable models.

Purpose of the Study:

To review existing single-omics atlases of cortical areas.
To highlight the potential of multi-omic single-cell studies for understanding human cortical development and function.

Main Methods:

Review of single-omics data (transcriptomic, epigenomic, metabolomic, proteomic) from mammalian models.
Discussion of advancements in "omics" technologies, imaging, and computational power.

Keywords:

cortex development multi-omic regions single-cell

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Last Updated: Oct 8, 2025

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex

Published on: September 5, 2018

Mapping the Emergent Spatial Organization of Mammalian Cells using Micropatterns and Quantitative Imaging

Mapping the Emergent Spatial Organization of Mammalian Cells using Micropatterns and Quantitative Imaging

Published on: April 30, 2019

Visualization of Cortical Modules in Flattened Mammalian Cortices

Visualization of Cortical Modules in Flattened Mammalian Cortices

Published on: January 22, 2018

Exploration of the potential for multi-omic single-cell analyses in human cortical research.

Main Results:

Single-omics atlases have significantly advanced our understanding of cortical area characteristics.
Technological progress enables more comprehensive molecular and structural profiling.

Conclusions:

Future multi-omic single-cell studies are essential for a deeper interrogation of the developing and adult human cortex.
Integrating diverse omics data will unlock new insights into the gene networks governing cortical arealization and function.