Smooth Endoplasmic Reticulum Clusters in Oocytes From Patients Who Received Intracytoplasmic Sperm Injections
Xue Wang1, YaLing Xiao1, ZhengYi Sun1
1Department of Gynecology Endocrine and Reproductive Center, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Frontiers in Physiology
|December 27, 2021
Summary
Smooth endoplasmic reticulum clusters (SERCs) in oocytes negatively impact blastocyst development speed and quality. This study found lower fertilization and good quality blastocyst rates in SERC-positive oocytes, suggesting a potential adverse effect on IVF outcomes.
Area of Science:
- Reproductive biology
- Embryology
- In vitro fertilization (IVF)
Background:
- Smooth endoplasmic reticulum clusters (SERCs) in oocytes have shown conflicting associations with blastocyst development.
- Understanding the impact of SERCs on oocyte quality and subsequent embryo development is crucial for improving IVF success rates.
Purpose of the Study:
- To evaluate the effect of SERCs in oocytes on blastocyst quality and development speed.
- To compare embryological, clinical, and neonatal outcomes between oocytes with and without SERCs.
Main Methods:
- Retrospective analysis of intracytoplasmic sperm injection (ICSI) cycles from 2016-2020.
- Comparison of SERC (+) oocytes (n=217) and SERC (-) oocytes (n=822).
- Statistical analysis including logistic regression to adjust for confounding factors.
Main Results:
- SERC (+) oocytes showed significantly lower fertilization rates (73.9% vs. 86.2%), good quality blastocyst rates (26.7% vs. 44.1%), and slower blastocyst development (44.4% vs. 63.4%) compared to SERC (-) oocytes.
- A higher proportion of SERC (+) oocytes resulted in trophectoderm (TE) grade C blastocysts (73.3% vs. 55.9%).
- Logistic regression confirmed that SERCs significantly affected the speed of blastocyst development (OR, 2.812; P=0.012).
Conclusions:
- The presence of SERCs in oocytes is associated with reduced blastocyst quality and slower development.
- SERCs may negatively impact key embryological parameters in IVF.
- Further research is warranted to elucidate the mechanisms behind SERC's adverse effects on oocyte quality and embryo development.
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