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Progress on Poxvirus E3 Ubiquitin Ligases and Adaptor Proteins
Haoran Cui1,2,3, Yaxian Zhang2,3, Leiliang Zhang1,2,3
1Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, China.
Frontiers in Immunology
|December 27, 2021
Summary
Poxviruses use E3 ubiquitin ligases and adaptor proteins to evade innate immunity. This review categorizes these viral proteins and discusses their roles in host-pathogen interactions.
Area of Science:
- Virology
- Immunology
- Molecular Biology
Background:
- Poxviruses possess diverse mechanisms to counteract host innate immunity.
- Poxvirus-encoded E3 ubiquitin ligases and adaptor proteins are key players in these evasion strategies.
Purpose of the Study:
- To review and categorize poxvirus-encoded E3 ubiquitin ligases and adaptor proteins.
- To provide mechanistic insights into how these viral proteins interact with and manipulate host innate immune components.
Main Methods:
- Literature review of existing research on poxvirus E3 ubiquitin ligases and adaptor proteins.
- Classification of these proteins based on functional domains and ubiquitin transfer mechanisms.
Main Results:
- Poxvirus E3 ubiquitin ligases and adaptor proteins are grouped into five categories: PRANC, ANK/BC, BBK, P28/RING, and MARCH.
- Many identified substrates of these viral proteins are components of the innate immune system.
Conclusions:
- Poxvirus E3 ubiquitin ligases and adaptor proteins are critical for viral immune evasion.
- Understanding these proteins offers insights into poxvirus-host interactions and potential therapeutic targets.
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