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Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
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TCM Regulates PI3K/Akt Signal Pathway to Intervene Atherosclerotic Cardiovascular Disease

Jiali Liu1, Pangao Xu2, Dekun Liu1

  • 1Faculty of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.

Evidence-Based Complementary and Alternative Medicine : Ecam
|December 27, 2021
PubMed

Insights

This study explores how the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) pathway influences atherosclerosis (AS). It also examines how traditional Chinese medicine (TCM) may regulate this pathway to treat AS.

Area of Science:

  • Cardiovascular Research
  • Molecular Biology
  • Pharmacology

Background:

  • Vascular endothelial injury initiates atherosclerosis (AS).
  • The phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway is crucial in AS pathogenesis.
  • PI3K/Akt signaling affects endothelial cytokines, macrophage polarization, and platelet function.

Purpose of the Study:

  • To analyze the PI3K/Akt signaling pathway's characteristics in AS.
  • To elucidate the PI3K/Akt pathway's role in AS pathogenesis.
  • To investigate traditional Chinese medicine's (TCM) regulation of the PI3K/Akt pathway in AS.

Main Methods:

  • Literature review of PI3K/Akt pathway in AS.
  • Analysis of TCM's therapeutic mechanisms targeting PI3K/Akt.
  • Synthesis of current research on PI3K/Akt and AS.

Main Results:

  • The PI3K/Akt pathway significantly impacts AS development and progression.
  • TCM demonstrates potential in modulating AS via the PI3K/Akt pathway.
  • Evidence suggests TCM offers a multi-target, low-side-effect approach to AS.

Conclusions:

  • Understanding the PI3K/Akt pathway is key to AS research.
  • TCM presents a promising avenue for AS treatment by targeting the PI3K/Akt pathway.
  • This review provides a foundation for clinical AS treatment and mechanism research.

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