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Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO): A Case Report
Amman Yousaf1,2, Shoaib Muhammad3, Basel Abdelazeem4
1Internal Medicine, McLaren Flint, Flint, USA.
Cureus
|December 27, 2021
Summary
Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) is a rare disorder causing bone and soft tissue changes. Early management with non-steroidal anti-inflammatory drugs (NSAIDs) proved effective for two patients with SAPHO syndrome.
Area of Science:
- Rheumatology
- Orthopedics
- Dermatology
Background:
- Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) is an uncommon adult-onset inflammatory disorder.
- It characteristically involves the bone and surrounding soft tissues, presenting with focal swelling and pain.
Observation:
- Radiological imaging, particularly CT and MRI, is crucial for diagnosis, revealing cortical thickening, decreased marrow cavity, bony erosion, and ligament ossification.
- Clinical presentation includes synovitis and joint effusions, often necessitating advanced imaging for definitive diagnosis.
Findings:
- The case series highlights two patients presenting with joint swellings, diagnosed with SAPHO syndrome.
- Both patients responded well to initial treatment with non-steroidal anti-inflammatory drugs (NSAIDs).
Implications:
- This suggests NSAIDs can be an effective first-line treatment for SAPHO syndrome.
- Further research into optimal management strategies for SAPHO is warranted.
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