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Author Spotlight: Oral Candida Diagnosis to Advance Clinical Treatment Regimen for pSS Patients
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A Hematologic Disease Disguised as Cutaneous Candidiasis.
Joana Couto1, Patricia Sobrosa1, Ana Afonso1
1Internal Medicine, Unidade Local de Saúde do Alto Minho, Viana do Castelo, PRT.
Cureus
|December 27, 2021
Summary
Langerhans cell histiocytosis, a rare myeloid neoplasm, can manifest in the skin. This case highlights its importance as a differential diagnosis for persistent skin conditions unresponsive to treatment.
Area of Science:
- Hematology
- Dermatology
- Oncology
Background:
- Langerhans cell histiocytosis (LCH) is a rare myeloid neoplasm affecting multiple organs, with skin involvement being common.
- Cutaneous candidiasis is a frequent fungal infection, but can sometimes be refractory to standard treatments.
Observation:
- A 44-year-old female presented with suspected persistent cutaneous candidiasis.
- Skin biopsy revealed Langerhans cell histiocytosis, confirmed by positive CD1a and S100 protein immunohistochemistry.
Findings:
- Langerhans cell histiocytosis can mimic refractory cutaneous fungal infections.
- Immunohistochemistry is crucial for diagnosing LCH in skin lesions.
Implications:
- Skin biopsy is essential for diagnosing unusual or refractory skin conditions.
- LCH diagnosis requires considering differential diagnoses beyond typical infections.
- Management of LCH is challenging due to inconsistent responses to therapies.
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