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Related Concept Videos

Metastasis02:30

Metastasis

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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Tumor Progression02:07

Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Related Experiment Video

Updated: Oct 8, 2025

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
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Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

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Osteosarcoma and Metastasis.

Gaohong Sheng1, Yuan Gao2, Yong Yang1

  • 1Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Frontiers in Oncology
|December 27, 2021
PubMed
Summary
This summary is machine-generated.

Osteosarcoma metastasis is a major cause of treatment failure. This review explores molecular mechanisms and therapeutic strategies to improve outcomes for metastatic osteosarcoma patients.

Keywords:
metabolismmetastasismicroenvironmentnoncoding RNAsosteosarcoma

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Area of Science:

  • Oncology
  • Molecular Biology
  • Translational Research

Background:

  • Osteosarcoma is the most common adolescent bone cancer.
  • Metastasis drives treatment failure and poor prognosis in osteosarcoma.
  • Current therapeutic strategies for metastatic osteosarcoma are limited.

Purpose of the Study:

  • To deepen the understanding of molecular mechanisms driving osteosarcoma metastasis.
  • To identify novel therapeutic targets and strategies for metastatic osteosarcoma.
  • To bridge basic research with clinical translation for osteosarcoma treatment.

Main Methods:

  • Comprehensive review of molecular, cellular, and animal studies.
  • Analysis of regulatory networks, signaling pathways, and key molecules.
  • Integration of findings across chemical, physical sciences, and biology.

Main Results:

  • Detailed examination of the metastatic process in osteosarcoma.
  • Exploration of the roles of microenvironment, osteoclasts, angiogenesis, metabolism, immunity, and noncoding RNAs.
  • Identification of potential druggable targets and therapeutic avenues.

Conclusions:

  • A deeper understanding of osteosarcoma metastasis is crucial for developing effective therapies.
  • Targeting specific molecular mechanisms and pathways offers promise for improving patient outcomes.
  • Integrated research approaches are essential for clinical translation in osteosarcoma treatment.