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Related Concept Videos

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Bone Cells and Tissue01:30

Bone Cells and Tissue

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Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
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Updated: Oct 8, 2025

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
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Recent Advances in Osteoclast Biological Behavior.

Yang Sun1, Jiangbi Li1, Xiaoping Xie1

  • 1Department of Orthopedics, The First Hospital of Jilin University, Changchun, China.

Frontiers in Cell and Developmental Biology
|December 27, 2021
PubMed
Summary

Osteoclasts are crucial for bone health and treating bone diseases. This review offers a comprehensive overview of osteoclast biology, including their origin, function, and interactions with osteoblasts.

Keywords:
apoptosisdifferentiationfunctionsintercellular interactionsoriginosteoclast

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Area of Science:

  • Bone biology and regenerative medicine
  • Cellular and molecular biology
  • Gerontology and aging research

Background:

  • Aging populations face increasing bone diseases like osteoporosis and osteoarthritis.
  • Osteoclasts play a vital role in maintaining bone homeostasis.
  • Existing reviews lack a comprehensive overview of osteoclast biology and recent advances.

Purpose of the Study:

  • To provide a complete overview of osteoclast biology.
  • To summarize recent research advances in osteoclast function.
  • To serve as a foundational resource for future osteoclast research.

Main Methods:

  • Literature review of osteoclast origin and differentiation.
  • Analysis of osteoclast apoptosis mechanisms.
  • Examination of osteoclast behavior changes and osteoblast coupling signals.

Main Results:

  • Detailed exploration of osteoclastogenesis pathways.
  • Discussion of factors influencing osteoclast apoptosis.
  • Elucidation of the intricate communication between osteoclasts and osteoblasts.

Conclusions:

  • Osteoclasts are key targets for managing bone-related diseases.
  • A comprehensive understanding of osteoclast biology is essential for therapeutic development.
  • This review consolidates current knowledge on osteoclasts for researchers.