Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glucagon-like Receptor Agonists01:24

Glucagon-like Receptor Agonists

465
Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
465
Regulation of Food Intake01:30

Regulation of Food Intake

867
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
867
Gastric Emptying01:16

Gastric Emptying

1.7K
Gastric emptying occurs when the stomach gradually releases chyme into the duodenum. When the stomach is distended, it triggers the release of gastrin, a hormone that promotes gastric acid secretion to aid in digestion. Additionally, stomach distension contributes to peristaltic waves that propel gastric contents toward the pyloric region. The gastroenteric reflex, on the other hand, primarily stimulates peristalsis in the intestines, facilitating the movement of contents further along the...
1.7K
TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

8.0K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
8.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

TORC1 inactivation induces a noncanonical, separase-independent cohesin degradation.

Bioscience, biotechnology, and biochemistry·2026
Same author

Ninjin'yoeito ameliorates deficits in self-care behaviors in a polyinosinic-polycytidylic acid-induced fatigue model via dopamine D2 receptor activation.

Journal of natural medicines·2026
Same author

Congenital Kir6.2 deficiency, but not acute K<sub>ATP</sub> channel blockade, attenuates apomorphine-induced locomotor activity in mice.

Pharmacology, biochemistry, and behavior·2026
Same author

SirT2 Inhibition is Associated with Improvements in Depression-like Behavior and Memory Impairment in Olfactory Bulbectomized Mice.

Molecular neurobiology·2026
Same author

AICAR improves depression-like behaviors and is associated with hippocampal AMPK activation and modulation of neurogenesis and neuroinflammation in a microbiota disruption model.

Neurochemistry international·2026
Same author

Dietary cobalt suppresses starch-induced succinate accumulation via colonic synthesis of vitamin B<sub>12</sub> and its analogues in rats.

The British journal of nutrition·2026

Related Experiment Video

Updated: Oct 8, 2025

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood
11:36

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood

Published on: April 28, 2016

9.4K

Ghrelin Enhancer, the Latest Evidence of Rikkunshito.

Chihiro Yamada1, Tomohisa Hattori1, Shunsuke Ohnishi2

  • 1Tsumura Kampo Research Laboratories, Tsumura & Co., Ibaraki, Japan.

Frontiers in Nutrition
|December 27, 2021
PubMed
Summary

Rikkunshito, a Japanese herbal medicine, enhances ghrelin secretion and signaling, offering potential benefits for gastrointestinal disorders, anorexia, and healthy aging. This review explores its therapeutic applications and latest research findings.

Keywords:
GHS-RKampoaginganorexiaghrelinrikkunshitostress

More Related Videos

Body Composition and Metabolic Caging Analysis in High Fat Fed Mice
10:28

Body Composition and Metabolic Caging Analysis in High Fat Fed Mice

Published on: May 24, 2018

15.7K
Fat Preference: A Novel Model of Eating Behavior in Rats
05:57

Fat Preference: A Novel Model of Eating Behavior in Rats

Published on: June 27, 2014

13.3K

Related Experiment Videos

Last Updated: Oct 8, 2025

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood
11:36

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood

Published on: April 28, 2016

9.4K
Body Composition and Metabolic Caging Analysis in High Fat Fed Mice
10:28

Body Composition and Metabolic Caging Analysis in High Fat Fed Mice

Published on: May 24, 2018

15.7K
Fat Preference: A Novel Model of Eating Behavior in Rats
05:57

Fat Preference: A Novel Model of Eating Behavior in Rats

Published on: June 27, 2014

13.3K

Area of Science:

  • Pharmacology
  • Gastroenterology
  • Herbal Medicine Research

Background:

  • Rikkunshito is a traditional Japanese Kampo herbal medicine with growing international research interest.
  • Its significance surged following the discovery of its role in promoting ghrelin secretion.
  • Research indicates Rikkunshito interacts with the ghrelin receptor (GHS-R1a), enhancing brain signaling.

Purpose of the Study:

  • To review existing research on Rikkunshito's effects, particularly its ghrelin-enhancing properties.
  • To present the latest research findings on Rikkunshito's therapeutic potential.
  • To consolidate evidence for Rikkunshito's efficacy in various medical conditions.

Main Methods:

  • Literature review of Rikkunshito research, including basic and clinical studies.
  • Analysis of studies investigating Rikkunshito's impact on ghrelin secretion and receptor activity.
  • Synthesis of evidence from research on gastrointestinal diseases, anorexia, and aging.

Main Results:

  • Rikkunshito administration promotes the secretion of the orexigenic peptide ghrelin.
  • It directly affects the ghrelin receptor (GHS-R1a), enhancing ghrelin signaling to the brain.
  • Evidence suggests efficacy for gastrointestinal issues, anorexia, and potentially healthy lifespan extension.

Conclusions:

  • Rikkunshito demonstrates significant potential as a therapeutic agent for various conditions.
  • Its mechanism involves modulating the ghrelin signaling pathway.
  • Further research is warranted to fully elucidate its applications in gastrointestinal health and aging.