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Related Experiment Videos

Computed tomographic findings in progressive supranuclear palsy.

H Saitoh, F Yoshii, Y Shinohara

    Neuroradiology
    |January 1, 1987
    PubMed
    Summary

    Progressive supranuclear palsy (PSP) patients show enlarged ventricles and cisterns on CT scans compared to controls and Parkinson's disease (PD) patients. This suggests PSP involves both brainstem and higher brain region damage.

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    Area of Science:

    • Neurology
    • Radiology
    • Neuroimaging

    Background:

    • Progressive supranuclear palsy (PSP) is a neurodegenerative disease.
    • Understanding PSP's pathological distribution is crucial for diagnosis and treatment.
    • Previous studies focused on infratentorial changes in PSP.

    Purpose of the Study:

    • To investigate supratentorial changes in progressive supranuclear palsy (PSP) using computed tomography (CT).
    • To compare CT findings in PSP patients with those in control subjects and Parkinson's disease (PD) patients.
    • To determine if PSP affects supratentorial structures.

    Main Methods:

    • Computed tomography (CT) scans of 6 PSP patients were analyzed.
    • Measurements of lateral ventricles, third ventricle, and prepontine cistern were taken.
    • PSP findings were compared with control and PD patient data.

    Main Results:

    • PSP patients exhibited significantly enlarged lateral ventricles compared to controls and PD patients.
    • The third ventricle and prepontine cistern were also significantly enlarged in PSP patients.
    • These findings indicate volumetric changes in supratentorial compartments.

    Conclusions:

    • Progressive supranuclear palsy (PSP) is associated with significant supratentorial abnormalities.
    • CT findings suggest lesions extend beyond the brainstem in PSP.
    • Enlarged ventricles and cisterns may serve as imaging biomarkers for PSP.

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