Effect of some endodontic sealers on cell migration in experimental granulomas

CRCS or calciobiotic root canal sealer (a calcium hydroxide-based sealer), Proco-sol and Tubliseal (both zinc oxide eugenol-based sealers), and Diaket-A (a polyvinyl-based sealer) were assessed for their relative cytotoxicities by their different cell migration effects by means of glass coverslip granulomas. Cytotoxicity was assessed by means of the influx of mononuclear cells or macrophages and their transformation into multinucleate giant cells. CRCS was shown to be the best sealer, followed by Proco-sol and Tubliseal. Diaket-A was the most cytotoxic of the sealers tested.