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Anti-ageing peptides and proteins for topical applications: a review

Mengyang Liu1, Shuo Chen1, Zhiwen Zhang2

  • 1School of Pharmacy, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.

Pharmaceutical Development and Technology
|December 27, 2021
PubMed

Insights

This review explores how anti-ageing peptides and proteins combat skin ageing caused by oxidative stress and UV radiation. It highlights advancements in delivering these compounds topically for improved skin health.

Area of Science:

  • Dermatology and Cosmetology
  • Biochemistry
  • Pharmaceutics

Background:

  • Skin ageing is primarily driven by oxidative stress from reactive oxygen species (ROS), with ultraviolet A (UVA) irradiation accounting for 80% of skin damage.
  • Anti-ageing peptides and proteins are crucial for neutralizing ROS and maintaining skin health.
  • Understanding the mechanisms and delivery pathways of these compounds is vital for effective anti-ageing strategies.

Purpose of the Study:

  • To review the theory of skin ageing, focusing on the role of anti-ageing peptides and proteins.
  • To summarize the effects, classification, and dermal transport of these compounds.
  • To discuss recent advancements in the topical delivery of anti-ageing peptides and proteins.

Main Methods:

  • Literature review of scientific articles on skin ageing, peptides, proteins, and dermal delivery.
  • Analysis of existing theories and research on anti-ageing compounds.
  • Synthesis of information on novel formulations and delivery strategies.

Main Results:

  • Peptides and proteins are effective in combating ROS-induced skin ageing.
  • Various transport pathways exist for these molecules across the skin barrier.
  • Significant progress has been made in developing advanced formulations for dermal delivery.

Conclusions:

  • Novel formulations and delivery strategies are essential for enhancing the efficacy of topical anti-ageing peptides and proteins.
  • Semi-solid dosage forms show promise for improved topical applicability.
  • Continued research in dermal delivery is key to advancing anti-ageing skincare.
Keywords:
Anti-ageingantioxidantsdermal deliverynanoparticulate drug delivery systemsproteins and peptidessemi-solid dosage forms

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