Related Experiment Video

Updated: Oct 8, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
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Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

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Updated picture of SARS-CoV-2 variants and mutations

Giuseppe Lippi1, Camilla Mattiuzzi2, Brandon M Henry3,4

  • 1Section of Clinical Biochemistry and School of Medicine, University of Verona, Verona, Italy.

Diagnosis (Berlin, Germany)
|December 27, 2021
PubMed

Insights

The SARS-CoV-2 pandemic continues globally, with evolving variants and mutations challenging vaccine and treatment effectiveness. This review details COVID-19 variants and mutations from late 2019 to late 2021.

Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, has resulted in millions of infections and deaths worldwide.
  • Preventive measures like lockdowns and masking show limited long-term efficacy.
  • Existing vaccines face challenges from low uptake, variable efficacy, and emerging SARS-CoV-2 variants.

Purpose of the Study:

  • To provide an updated overview of SARS-CoV-2 variants and mutations.
  • To track the emergence and characteristics of new strains.
  • To inform ongoing strategies against the evolving pandemic.

Main Methods:

  • Review of scientific literature and public health data.
  • Analysis of SARS-CoV-2 genomic sequences.
  • Tracking of reported variants and mutations.

Main Results:

  • Significant global burden of COVID-19 with ongoing infections and fatalities.
  • Identification of numerous SARS-CoV-2 variants and mutations since late 2019.
  • Emergence of new variants potentially impacting vaccine and treatment efficacy.

Conclusions:

  • The continuous evolution of SARS-CoV-2 necessitates ongoing monitoring of variants and mutations.
  • Adaptation of public health strategies and medical interventions is crucial.
  • Further research is needed to address the challenges posed by new viral strains.

Keywords:
COVID-19SARS-CoV-2mutationsvariants

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