Related Experiment Video
Updated: Oct 8, 2025

Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
Re-exposure to iodinated contrast media in two patients with prior severe hypersensitivity reaction
Objective:
Most allergic reactions to iodinated contrast media can be managed using a pre-treatment protocol involving corticosteroids and antihistamines. However, under certain circumstances, patients may experience severe allergic symptoms despite pre-treatment.
Case Report:
Two Chinese men with a history of severe contrast allergy and unstable angina underwent a desensitization protocol that allowed for successful percutaneous coronary intervention.
Conclusion:
Rapid desensitization is an effective and safe strategy that may allow other patients with similar allergies to successfully undergo angiography that requires the use of radiocontrast media.
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