Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nose and Nasal Cavity01:24

Nose and Nasal Cavity

5.4K
The nose is composed of an observable exterior segment (external nose) and an internal segment within the skull known as the nasal cavity (internal nose). The external nose, visible on the face, consists of a framework of bone and hyaline cartilage enveloped in skin and muscle and lined with a mucous membrane. This structure is supported by the frontal bone, nasal bones, and maxillary bone and is supplemented by a cartilaginous framework comprising the septal nasal cartilage, lateral nasal...
5.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

scRNA-seq and genomics analyses reveal key mechanisms of inverted papilloma-associated sinonasal squamous cell carcinoma malignant transformation.

bioRxiv : the preprint server for biology·2026
Same author

North American Delphi Consensus Study on Sinonasal Malignancy Survivorship Care.

International forum of allergy & rhinology·2026
Same author

Bintrafusp alfa for patients with recurrent or metastatic olfactory neuroblastoma.

Cancer immunology, immunotherapy : CII·2026
Same author

Spatial cellular order underlies locally-confined mechanisms of immune resistance in oropharyngeal cancer.

Nature communications·2026
Same author

Multidisciplinary Consensus Statement for Appropriate Evaluation and Workup of Sinonasal Masses.

JAMA otolaryngology-- head & neck surgery·2026
Same author

Endoscopic Endonasal Dacryocystectomy for Tumors Involving the Nasolacrimal Duct and Lacrimal Sac.

Journal of neurological surgery. Part B, Skull base·2026

Related Experiment Video

Updated: Oct 8, 2025

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
07:00

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Published on: February 28, 2019

6.0K

Emerging concepts in sinonasal tumor research.

Diana C Lopez1,2, Andrew E Wadley1,3, Nyall R London1,4,5

  • 1Sinonasal and Skull Base Tumor Program, National Institute on Deafness and Other Communication Disorders, National Institutes of Health; Bethesda, Maryland.

Current Opinion in Otolaryngology & Head and Neck Surgery
|December 27, 2021
PubMed
Summary

Advances in understanding rare sinonasal cancers like sinonasal undifferentiated carcinoma (SNUC) and intestinal-type adenocarcinoma (ITAC) reveal new genetic targets and therapeutic strategies. These findings offer hope for improved disease control and patient outcomes.

More Related Videos

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
07:43

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

19.1K
Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
09:53

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Published on: July 5, 2021

3.8K

Related Experiment Videos

Last Updated: Oct 8, 2025

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
07:00

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Published on: February 28, 2019

6.0K
Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
07:43

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

19.1K
Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
09:53

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Published on: July 5, 2021

3.8K

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Sinonasal malignancies are rare, aggressive, and often diagnosed late.
  • Limited research exists on the specific genetic and molecular characteristics of these tumors.

Purpose of the Study:

  • To review recent advances in the diagnosis, treatment, and scientific understanding of sinonasal undifferentiated carcinoma (SNUC), intestinal-type adenocarcinoma (ITAC), and olfactory neuroblastoma (ONB).

Main Methods:

  • Review of recent scientific literature focusing on genetic and molecular characterization of SNUC, ITAC, and ONB.
  • Analysis of studies investigating novel diagnostic and therapeutic approaches.

Main Results:

  • Identification of SMARCB1 and IDH2 mutations in SNUC, suggesting potential for tumor subdivision.
  • Evidence supporting induction chemotherapy for SNUC.
  • Discovery of targetable somatic mutations in ITAC.
  • Characterization of the tumor microenvironment in ITAC and ONB, indicating potential for immune checkpoint inhibition.

Conclusions:

  • Current research provides promising insights into the genetic and molecular profiles of rare sinonasal tumors.
  • These discoveries are driving the development of novel therapeutic strategies.
  • Continued multi-institutional collaboration is crucial for advancing disease control and improving patient outcomes in sinonasal cancer.