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Related Experiment Video

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Reduced Electroencephalogram Complexity in Postoperative Delirium.

Sean Tanabe1, Maggie Parker2, Richard Lennertz2

  • 1Center for Consciousness Science, Department of Anesthesiology, University of Michigan, Ann Arbor, Michigan, USA.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
|December 27, 2021
PubMed
Summary
This summary is machine-generated.

Delirium reduces electroencephalogram (EEG) complexity, indicating less brain information processing. This reduction in Lempel-Ziv Complexity (LZC) correlates with delirium severity, suggesting altered cortical function beyond peripheral inflammation.

Keywords:
Age-related pathologyInflammationNeurodegeneration

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Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Critical Care Medicine

Background:

  • Delirium is linked to electroencephalogram (EEG) slowing and impaired brain connectivity.
  • Reduced cortical information processing is a suspected mechanism in delirium.

Purpose of the Study:

  • To investigate if delirium is associated with a reduction in cortical information processing, measured by Lempel-Ziv Complexity (LZC).
  • To correlate changes in LZC with delirium severity and peripheral inflammation markers.

Main Methods:

  • Analyzed EEG data from 89 post-surgery patients using Lempel-Ziv Complexity (LZC) and normalized LZC (LZCn).
  • Correlated perioperative changes in LZC/LZCn with delirium severity (Delirium Rating Scale-98 [DRS]) and monocyte chemoattractant protein-1 levels.
  • Employed scalp-wide threshold-free cluster enhancement for statistical correction.

Main Results:

  • LZC negatively correlated with DRS across the scalp (peak r2 = .199, p < .001), indicating reduced complexity with increased delirium severity.
  • Normalized LZC (LZCn) also showed significant negative correlations, primarily in posterior regions (peak r2 = .076, p = .010).
  • LZC in posterior/temporal regions negatively correlated with monocyte chemoattractant protein-1 (peak r2 = .264, p < .001), but LZCn did not.

Conclusions:

  • EEG signal complexity decreases proportionally to delirium severity, suggesting reduced cortical information processing.
  • Peripheral inflammation may not fully explain the observed EEG changes, implying other pathogenic mechanisms in delirium.