Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

5.5K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
5.5K
Classification of Skeletal Muscle Fibers01:48

Classification of Skeletal Muscle Fibers

57.2K
Skeletal muscles continuously produce ATP to provide the energy that enables muscle contractions. Skeletal muscle fibers can be categorized into three types based on differences in their contraction speed and how they produce ATP, as well as physical differences related to these factors. Most human muscles contain all three muscle fiber types, albeit in varying proportions.
Slow-Twitch Muscle Fibers
Slow oxidative, muscle fibers appear red due to large numbers of capillaries and high levels of...
57.2K
Tumor Progression02:07

Tumor Progression

6.6K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.6K
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

4.2K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.2K
Classification of Epithelial Tissues: Overview01:22

Classification of Epithelial Tissues: Overview

17.0K
Epithelial tissues are classified according to the shape of the cells and the number of cell layers formed. Cell shapes can be squamous (flattened and thin), cuboidal (square-like, as wide as it is tall), or columnar (rectangular, taller than it is wide). Additionally, the nucleus shape helps identify the type of epithelial cells. Squamous cells have flattened disc-shaped nuclei, cuboidal cells have spherical nuclei, and columnar cells have elongated nuclei.
Based on the number of cell layers,...
17.0K
Abnormal Proliferation02:23

Abnormal Proliferation

4.7K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Proteogenomic profiling of soft tissue leiomyosarcoma reveals distinct molecular subtypes with divergent outcomes and therapeutic vulnerabilities.

bioRxiv : the preprint server for biology·2025
Same author

Low-Grade Fibro-Osseous Lesions With Isolated Chromosome 12 Chromothripsis: A Distinct Entity Or a Low-Grade Central Osteosarcoma With a Novel Driver?

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc·2025
Same author

GLI1-altered mesenchymal tumors of the head and neck.

Seminars in diagnostic pathology·2025
Same author

Soft tissue sarcoma with MN1 gene fusions: a report of three cases with aggressive clinical behavior.

The Journal of pathology·2025
Same author

A Need for Multi-Institutional Collaboration for Deep Learning-Driven Assessment of Osteosarcoma Treatment Response.

The American journal of pathology·2025
Same author

Case report: Clinical and molecular features of renal gastrointestinal tumor.

Frontiers in oncology·2025
Same journal

Flat epithelial atypia of the breast: a pragmatic, context-integrated diagnostic framework within a biological continuum.

Histopathology·2026
Same journal

Myxoid neoplasms with MAP3K kinase fusion: a study of 39 cases.

Histopathology·2026
Same journal

TROP2 immunoreactivity in pulmonary large cell neuroendocrine carcinoma.

Histopathology·2026
Same journal

Malignant adenomyoepithelioma of the breast: seven cases illustrating morphological diversity and diagnostic challenges.

Histopathology·2026
Same journal

A CRX-positive RB1-deficient bone tumour with a retinoblastoma-like DNA methylation profile.

Histopathology·2026
Same journal

Perivascular epithelioid cell tumours of the genitourinary tract: clinicopathological features and molecular landscape.

Histopathology·2026
See all related articles

Related Experiment Video

Updated: Oct 8, 2025

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas
09:21

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Published on: September 13, 2019

7.3K

Evolving classification of rhabdomyosarcoma.

Narasimhan P Agaram1

  • 1Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Histopathology
|December 27, 2021
PubMed
Summary
This summary is machine-generated.

Rhabdomyosarcomas are the most common childhood soft tissue sarcomas. This review details their subtypes, diagnostic features, and classification evolution.

Keywords:
FOXO1MYOD1alveolarembryonalpleomorphicrhabdomyosarcomaspindle cell/sclerosing

More Related Videos

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
08:57

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

2.2K
Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

19.3K

Related Experiment Videos

Last Updated: Oct 8, 2025

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas
09:21

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Published on: September 13, 2019

7.3K
Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
08:57

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

2.2K
Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

19.3K

Area of Science:

  • Pediatric Oncology
  • Pathology
  • Genetics

Background:

  • Rhabdomyosarcomas represent the largest group of pediatric soft tissue sarcomas in the US.
  • These tumors affect approximately 4.5 million individuals under 20 years old.
  • Accurate classification is crucial for effective treatment and prognosis.

Purpose of the Study:

  • To review the historical evolution of rhabdomyosarcoma classification.
  • To detail the key histomorphological and genetic features of each subtype.
  • To outline the current diagnostic approaches for rhabdomyosarcomas.

Main Methods:

  • Literature review of rhabdomyosarcoma classification and diagnostics.
  • Analysis of clinicopathological and genetic data for different subtypes.
  • Synthesis of information on embryonal, alveolar, spindle cell/sclerosing, and pleomorphic subtypes.

Main Results:

  • Rhabdomyosarcomas are classified into four main subtypes: embryonal, alveolar, spindle cell/sclerosing, and pleomorphic.
  • Each subtype exhibits distinct morphological characteristics and specific genetic abnormalities.
  • The classification system has evolved significantly based on accumulating clinicopathological and genetic insights.

Conclusions:

  • Understanding the distinct features of each rhabdomyosarcoma subtype is essential for accurate diagnosis.
  • The classification and diagnostic approach to rhabdomyosarcomas have been refined by integrating histomorphology and genetic findings.
  • This review provides a comprehensive overview for clinicians and researchers involved in pediatric sarcoma management.