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[Systematic ileocolonoscopy in seronegative spondylarthropathies]
Revue Du Rhumatisme Et Des Maladies Osteo-Articulaires
|March 1, 1987
Summary
Minimal ileorectal inflammation is present in patients with seronegative spondylo-arthropathy. This finding suggests a potential role in the disease
Area of Science:
- Gastroenterology and Rheumatology
- Immunology
Context:
- Seronegative spondylo-arthropathy (SnSPA) is a group of inflammatory diseases.
- Previous studies noted ileitis in patients with reactive arthritis and HLA B27 antigen.
Purpose:
- To investigate the presence of ileorectal inflammation in patients with seronegative spondylo-arthropathy.
- To compare findings with a control group suffering from gastrointestinal disorders.
Summary:
- Systematic ileo-colonoscopy was performed on 30 SnSPA patients and 18 controls.
- Macroscopic minimal abnormalities (erythematous patches, micro-ulcerations) were found in 10 SnSPA patients vs. 0 controls (p<0.02).
- Histological analysis revealed increased ileal and rectal inflammation (lympho-plasmacytic infiltration) in SnSPA patients compared to controls (p<0.05).
Impact:
- Suggests minimal ileorectal inflammation is a feature of seronegative spondylo-arthropathy.
- This inflammation may influence the pathogenesis and progression of SnSPA.
- Highlights the importance of gastrointestinal evaluation in SnSPA management.