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Updated: Oct 8, 2025
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An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat
Published on: May 19, 2020
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Impact of Anchor Location on Mitral Neochordae Forces: An In Vitro Study
Vahid Sadri1, Keshav Kohli1, Jorge H Jimenez1
1Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia.
The Annals of Thoracic Surgery
|December 27, 2021
Summary
Artificial neochordae effectively corrected mitral regurgitation. Central neochordae required higher force, regardless of anchor location, demonstrating their critical role in mitral valve repair.
Area of Science:
- Biomedical Engineering
- Cardiovascular Research
- Surgical Innovation
Background:
- Mitral regurgitation is a common cardiac condition.
- Neochordae implantation is a promising surgical technique for mitral valve repair.
- Understanding force distribution is crucial for optimizing neochordae performance.
Purpose of the Study:
- To investigate force distribution in artificial neochordae.
- To compare forces across different leaflet insertion sites (P2Lateral, P2Center, P2Medial).
- To evaluate the impact of ventricular anchoring locations on neochordae forces.
Main Methods:
- Utilized a left heart simulator with seven porcine mitral valves.
- Implanted expanded polytetrafluoroethylene neochordae from various ventricular anchor points.
- Quantified neochordae forces needed to restore mitral valve coaptation after inducing regurgitation.
Main Results:
- Central neochordae (P2Center) consistently required significantly higher forces than lateral neochordae (P2Lateral, P2Medial).
- Force differences were independent of ventricular anchoring origins (apex, base, tip).
- Forces at P2Lateral and P2Medial sites were not statistically different.
Conclusions:
- Artificial neochordae effectively corrected induced mitral regurgitation.
- P2Center neochordae exert greater force, highlighting their importance in restoring valve function.
- Findings guide optimal placement of neochordae for mitral valve repair.
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