Positive direct antiglobulin test results after intravenous immune globulin administration

The authors report a case of passive red cell sensitization caused by antibodies received during an infusion of intravenous immune globulin. The patient had a positive direct antiglobulin test but showed no signs of hemolysis. The intravenous immune globulin product contained antibodies against four red cell antigens. These adverse reactions should be considered in the laboratory evaluation and clinical care of patients who receive intravenous immune globulin.