Bacteria from Infectious Particles to Cell Based Anticancer Targeted Drug Delivery Systems

Area of Science:

• Biotechnology
• Nanomedicine
• Materials Science

Background:

• Bacterial ghosts (BGs) are nonliving, empty bacterial cell envelopes retaining original morphology and antigenicity.
• They possess inherent bioadhesive properties, making them suitable for targeted delivery applications.
• Recent research highlights BGs as a promising platform for advanced drug delivery systems (DDS).

Purpose of the Study:

• To review the impact of bacterial ghosts on drug delivery and targeting.
• To explore the diverse applications of BGs, including vaccine and cancer therapy.
• To discuss the synthesis, unique properties, and application principles of BGs in oncology.

Main Methods:

• Literature review of studies on bacterial ghosts as drug delivery systems.
• Analysis of research on BG applications in vaccine development and cancer therapy.
• Examination of synthesis methods, safety, and stability of BGs for drug delivery.

Main Results:

• Bacterial ghosts demonstrate significant potential as versatile drug delivery vehicles for DNA, peptides, and drugs.
• BG-based DDS have garnered substantial attention for their efficacy in drug targeting and therapeutic applications.
• Applications span vaccine development, tumor therapy, and targeted drug delivery in cancer treatment.

Conclusions:

• Bacterial ghosts offer a unique and promising platform for advanced drug delivery and targeting.
• Their inherent properties, safety profile, and stability support their use in various therapeutic areas, particularly cancer.
• Further research and development are crucial for realizing the full potential of bacterial ghosts in medicine.