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Cyclodextrin-Modified Nanomaterials for Drug Delivery: Classification and Advances in Controlled Release and
Daniel Andrés Real1,2, Karen Bolaños1,2,3, Josefina Priotti4
1Laboratorio de Nanobiotecnología y Nanotoxicología, Departamento de Química Farmacológica y Toxicológica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago 8380544, Chile.
Pharmaceutics
|December 28, 2021
Summary
Cyclodextrin (CD) and nanomaterial combinations enhance drug delivery by improving solubility and bioavailability. This review details various CD-based nanosystems for optimized pharmaceutical formulations.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
- Nanotechnology
Background:
- Cyclodextrins (CDs) are widely used to address poor solubility, instability, and low bioavailability of active pharmaceutical ingredients.
- Combining CD derivatives with nanomaterials offers a promising strategy for advanced drug delivery systems.
Purpose of the Study:
- To provide a comprehensive review and critical appraisal of CD-modified and CD-based nanomaterials for drug delivery.
- To highlight nanosystems designed for controlled release and enhanced in vivo bioavailability.
Main Methods:
- Literature review and critical analysis of existing research on CD-based nanocarriers.
- Categorization and discussion of various nanomaterial types incorporating CDs.
Main Results:
- Overview of diverse CD-based nanocarriers including lipid-based, polymeric, nanosponges, graphene, mesoporous silica, plasmonic, magnetic nanoparticles, quantum dots, and others.
- Emphasis on systems demonstrating controlled drug release and improved bioavailability in vivo.
Conclusions:
- CD-modified nanomaterials represent a significant advancement in overcoming drug delivery challenges.
- These integrated nanosystems hold great potential for developing optimized and effective pharmaceutical formulations.
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