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Orodispersible Films: A Delivery Platform for Solid Lipid Nanoparticles?

Denise Steiner^1,2, Jakob F Emmendörffer¹, Heike Bunjes^1,2

¹Institut für Pharmazeutische Technologie und Biopharmazie, Technische Universität Braunschweig, Mendelssohnstraße 1, 38106 Braunschweig, Germany.

|December 28, 2021

Summary

Hydroxypropyl methyl cellulose (HPMC) orodispersible films effectively encapsulate solid lipid nanoparticles, enhancing drug delivery. This formulation maintains nanoparticle integrity and improves mechanical properties, offering a promising oral drug delivery platform.

Keywords:

dual centrifugation nanotechnology poorly water-soluble drug solid dosage form triglycerides

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Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

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Published on: February 8, 2017

Area of Science:

Pharmaceutical Sciences
Materials Science
Nanotechnology

Background:

Poor bioavailability of new active pharmaceutical ingredients (APIs) necessitates advanced formulation strategies.
Solid lipid nanoparticles (SLNs) offer a potential solution for enhancing API delivery.
Orodispersible films (ODFs) are an emerging oral drug delivery platform with demonstrated suitability for nanoparticle administration.

Purpose of the Study:

To evaluate hydroxypropyl methyl cellulose (HPMC) film matrix as a delivery platform for SLNs.
To assess the feasibility of incorporating high lipid content into HPMC films containing SLNs.
To investigate the impact of ODF formulation on the polymorphic transformation of lipid nanoparticles.

Main Methods:

Formulation of SLNs within an HPMC film matrix.
Characterization of lipid content and nanoparticle integrity in the ODFs.
Evaluation of mechanical properties (tensile strength, elongation) of the HPMC films.
Analysis of lipid polymorphic transformations (α- to β-polymorph) after processing into ODFs.

Main Results:

High lipid contents (up to 54 wt.%) were achieved in the HPMC film matrix without compromising the nanoparticulate state.
The developed ODFs exhibited favorable mechanical properties, including good tensile strength and elongation before breakage.
Processing into ODFs significantly reduced the transformation of lipid particles from the metastable α- to the stable β-polymorph.

Conclusions:

HPMC-based ODFs are a suitable and innovative platform for the delivery of SLNs.
This formulation approach preserves nanoparticle integrity and offers improved mechanical characteristics.
The reduced polymorphic transformation of lipids in ODFs holds significant potential for API-loaded lipid nanoparticles.