Formulation and Characterization of an Effervescent Hydrogen-Generating Tablet

Area of Science:

• Pharmacology and Materials Science
• Investigating novel therapeutic delivery systems.

Background:

• Molecular hydrogen (H2) shows therapeutic potential for inflammatory and oxidative stress-related diseases.
• Magnesium-containing effervescent tablets offer a viable oral delivery strategy for medical hydrogen gas.
• Saccharide-based excipients are key components in effervescent tablet formulations.

Purpose of the Study:

• To evaluate the impact of various saccharides on the properties of hydrogen-generating effervescent tablets.
• To optimize tablet formulation for enhanced hydrogen generation and acceptable mechanical characteristics.
• To identify suitable excipients for improved oral delivery of molecular hydrogen.

Main Methods:

• Dry granulation technique used for tablet preparation.
• Assessment of morphological and mechanical tablet properties.
• Evaluation of hydrogen generation rates and disintegration times.
• Screening of saccharide-based fillers and lubricant effects.

Main Results:

• Mannitol demonstrated superior performance compared to other saccharides, significantly accelerating hydrogen generation.
• Tablets formulated with mannitol exhibited favorable mechanical properties and rapid disintegration.
• Adipic acid was selected as the optimal lubricant due to regulatory compliance.

Conclusions:

• Mannitol is a highly effective saccharide excipient for optimizing hydrogen-generating effervescent tablets.
• The optimized formulation facilitates efficient oral delivery of molecular hydrogen for therapeutic applications.
• Further research can build upon these findings for advanced hydrogen-based medical treatments.