Cameroonian Spice Extracts Modulate Molecular Mechanisms Relevant to Cardiometabolic Diseases in SW 872 Human
Achille Parfait Atchan Nwakiban1, Anna Passarelli2, Lorenzo Da Dalt2
1Department of Biochemistry, Faculty of Science, University of Dschang, Dschang P.O. Box 96, Cameroon.
Abstract:
The molecular pathophysiology of cardiometabolic diseases is known to be influenced by dysfunctional ectopic adipose tissue. In addition to lifestyle improvements, these conditions may be managed by novel nutraceutical products. This study evaluatedthe effects of 11 Cameroonian medicinal spice extracts on triglyceride accumulation, glucose uptake, reactive oxygen species (ROS) production and interleukin secretion in SW 872 human adipocytes after differentiation with 100 µM oleic acid. Triglyceride content was significantly reduced by all spice extracts. Glucose uptake was significantly increased by Tetrapleura tetraptera, Aframomum melegueta and Zanthoxylum leprieurii. Moreover, Xylopia parviflora, Echinops giganteus and Dichrostachys glomerata significantly reduced the production of ROS. Concerning pro-inflammatory cytokine secretion, we observed that Tetrapleura tetraptera, Echinops giganteus, Dichrostachys glomerata and Aframomum melegueta reduced IL-6 secretion. In addition, Xylopia parviflora, Monodora myristica, Zanthoxylum leprieurii, and Xylopia aethiopica reduced IL-8 secretion, while Dichrostachys glomerata and Aframomum citratum increased it. These findings highlight some interesting properties of these Cameroonian spice extracts in the modulation of cellular parameters relevant to cardiometabolic diseases, which may be further exploited, aiming to develop novel treatment options for these conditions based on nutraceutical products.
Insights
Cameroonian medicinal spice extracts show promise for managing cardiometabolic diseases by reducing triglycerides, enhancing glucose uptake, and lowering oxidative stress and inflammation in human fat cells.
Area of Science:
- Pharmacology
- Nutraceuticals
- Cell Biology
Background:
- Cardiometabolic diseases are linked to dysfunctional ectopic adipose tissue.
- Nutraceuticals offer potential management strategies alongside lifestyle changes.
Purpose of the Study:
- To evaluate the effects of 11 Cameroonian medicinal spice extracts on cellular parameters relevant to cardiometabolic diseases.
- To assess impacts on triglyceride accumulation, glucose uptake, reactive oxygen species (ROS), and interleukin secretion in human adipocytes.
Main Methods:
- SW 872 human adipocytes were differentiated using oleic acid.
- Cells were treated with 11 Cameroonian medicinal spice extracts.
- Measurements included triglyceride content, glucose uptake, ROS production, and IL-6/IL-8 secretion.
Main Results:
- All spice extracts significantly reduced triglyceride content.
- Specific extracts enhanced glucose uptake (T. tetraptera, A. melegueta, Z. leprieurii).
- Several extracts reduced ROS production (X. parviflora, E. giganteus, D. glomerata) and modulated IL-6/IL-8 secretion.
Conclusions:
- Cameroonian spice extracts possess properties beneficial for modulating cellular pathways implicated in cardiometabolic diseases.
- These findings support the development of novel nutraceutical-based treatments for cardiometabolic conditions.
