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Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
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Lactate Threshold Training Program on Patients with Multiple Sclerosis: A Multidisciplinary Approach.

Alessandra Amato1, Paolo Ragonese2, Sonia Ingoglia1

  • 1Department of Psychology, Educational Science and Human Movement, Research Unit, University of Palermo, 90100 Palermo, Italy.

Nutrients
|December 28, 2021
PubMed
Summary

Lactate threshold training improved physical and mental health in multiple sclerosis (MS) patients. This exercise regimen boosted self-efficacy and self-esteem while positively influencing neurotrophic factors and reducing inflammation.

Keywords:
BDNFDHEASdiet habitsmultiple sclerosisneurotrophinsphysical activity

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Area of Science:

  • Neurology
  • Exercise Physiology
  • Neuroscience

Background:

  • Multiple Sclerosis (MS) significantly impacts quality of life, often causing chronic fatigue and psychological distress.
  • Physical activity is recognized for its potential to improve well-being in neurological conditions.
  • Lactate threshold training offers a targeted approach to exercise, potentially addressing bio-psycho-physical deficits.

Purpose of the Study:

  • To investigate the bio-psycho-physical effects of lactate threshold training in multiple sclerosis patients.
  • To assess the impact of this training on chronic fatigue, mental health, and neurotrophic factors.
  • To evaluate changes in self-efficacy, self-esteem, and relevant biomarkers.

Main Methods:

  • Eight individuals with multiple sclerosis underwent a 12-week biweekly lactate threshold training program.
  • Physical, psychological, and hematochemical parameters were measured at baseline (T0), post-training (T1), and 9-month follow-up (T2).
  • Dietary habits were also assessed throughout the study.

Main Results:

  • Lactate threshold training positively influenced brain-derived neurotrophic factor (BDNF) and dehydroepiandrosterone sulfate (DHEAS) levels.
  • A decrease in baseline lactate levels was observed post-training, indicating improved energy substrate utilization.
  • Significant increases in self-efficacy for managing worries and concerns, alongside enhanced self-esteem, were noted.

Conclusions:

  • Lactate threshold training, combined with dietary habits, demonstrates synergistic benefits for inflammation, neural plasticity, and neuroprotection in MS.
  • This training approach shows promise in preventing MS symptom progression and improving overall patient well-being.
  • The study highlights the significant psychological and emotional benefits of physical exercise for individuals with multiple sclerosis.