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Infant Formula with Added Bovine Milk Fat Globule Membrane and Modified Iron Supports Growth and Normal Iron Status

James Hedrick1, Michael Yeiser2, Cheryl L Harris3

  • 1Kentucky Pediatrics, 201 South 5th Street, Bardstown, KY 40004, USA.

Nutrients
|December 28, 2021
PubMed

Insights

Adding bovine milk fat globule membrane (bMFGM) to infant formula supports healthy growth and iron status in infants. This study found no significant differences in growth or iron markers between formulas with and without bMFGM.

Area of Science:

  • Pediatrics
  • Nutrition Science
  • Biochemistry

Background:

  • Bovine milk fat globule membrane (bMFGM) components are hypothesized to support infant brain development.
  • Infant formulas (IFs) are evolving to better mimic human milk composition.
  • The role of bMFGM in infant nutrition requires further investigation.

Purpose of the Study:

  • To evaluate the impact of added bMFGM and modified nutrient profiles in infant formula on infant growth, tolerance, and iron status.
  • To compare a novel infant formula containing bMFGM with a standard formula.
  • To assess safety and efficacy markers throughout the first year of life.

Main Methods:

  • A double-blind, prospective trial randomized healthy term infants to receive either a control or an investigational infant formula (INV-MFGM) containing bMFGM.
  • Formulas differed in protein, iron, arachidonic acid (ARA), and bMFGM content.
  • Growth, tolerance (stool, fussiness, gassiness), and iron status (hemoglobin, hematocrit) were monitored up to 365 days.

Main Results:

  • No significant differences were observed in the primary outcome of weight gain rate between 14-120 days of age.
  • Growth, tolerance indicators, and study completion rates were similar between the control and INV-MFGM groups.
  • Iron status markers, including hemoglobin and hematocrit, and incidence of anemia at one year of age showed no group differences.

Conclusions:

  • Infant formula supplemented with bMFGM, modified protein, iron, and ARA is well-tolerated in healthy term infants.
  • This formula supports adequate growth throughout the first year of life.
  • The inclusion of bMFGM in infant formula supports normal iron status at one year of age.

Keywords:
growthinfant feedinginfant formulairon statusmilk fat globule membrane

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