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Propofol combined with nitrous oxide-oxygen for induction and maintenance of anaesthesia
Abstract:
After a bolus of 2 mg/kg, propofol was given by continuous infusion (150 micrograms/kg/minute for 30 minutes and then 100 micrograms/kg/minute) supplemented with nitrous oxide for anaesthesia during ear surgery in 12 patients. Cardiovascular changes were not significant except for a decrease in heart rate after 60 minutes. Acid-base balance was unaffected by the amount of fatty emulsion. Cortisol levels showed a nonsignificant decrease during the prolonged administration of propofol but had recovered completely by one hour following anaesthesia. Mean blood concentrations of propofol were 10.5 micrograms/ml (SEM 1.2) at the onset of unconsciousness, between 3.4 and 4.5 micrograms/ml during continuous infusion and 2.9 micrograms/ml (SEM 0.3) on awakening. Patients opened their eyes 6 minutes (SEM 1) after discontinuation of the infusion, and were responsive at 7.5 minutes (SEM 0.5), which suggests that propofol infusion can be used safely for surgery of 2 hours' duration.
Insights
Propofol infusion anesthesia, supplemented with nitrous oxide, proved safe for 2-hour ear surgeries. Cardiovascular and acid-base balance remained stable, with rapid recovery post-anesthesia.
Area of Science:
- Anesthesiology
- Pharmacology
Background:
- Propofol is a widely used intravenous anesthetic agent.
- Continuous infusion of propofol offers potential advantages for prolonged surgical procedures.
Purpose of the Study:
- To evaluate the safety and efficacy of propofol infusion combined with nitrous oxide for anesthesia during ear surgery.
- To assess cardiovascular and acid-base balance changes during propofol infusion anesthesia.
Main Methods:
- 12 patients undergoing ear surgery received an initial propofol bolus followed by a continuous infusion.
- Anesthesia was supplemented with nitrous oxide.
- Cardiovascular parameters, acid-base balance, and cortisol levels were monitored.
Main Results:
- Cardiovascular changes were minimal, with only a slight decrease in heart rate observed.
- Acid-base balance and cortisol levels remained largely unaffected by the anesthetic regimen.
- Patients demonstrated rapid recovery, with eye-opening at 6 minutes and responsiveness at 7.5 minutes post-infusion discontinuation.
Conclusions:
- Propofol infusion anesthesia, supplemented with nitrous oxide, is a safe and effective option for surgeries lasting up to 2 hours.
- The anesthetic regimen is well-tolerated, with stable physiological parameters and predictable recovery times.