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Batteryless, Miniaturized Implantable Glucose Sensor Using a Fluorescent Hydrogel.

Hyeonkeon Lee1,2, Jongheon Lee1,2, Honghyeon Park1,2

  • 1Department of Electronics and Information Convergence Engineering (BK21 Four), Kyung Hee University, Yong-in 17104, Korea.

Sensors (Basel, Switzerland)
|December 28, 2021
PubMed
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We developed a tiny, wireless biomedical sensor system for continuous glucose monitoring. This low-power device uses backscattered communication, overcoming power limitations for mm-sized implants in tissues.

Area of Science:

  • Biomedical Engineering
  • Microsystems Engineering
  • Sensor Technology

Background:

  • Continuous glucose monitoring is crucial for diabetes management.
  • Existing implantable biomedical devices face power limitations, hindering miniaturization to millimeter (mm) scale.
  • Developing mm-sized, low-power devices for in-tissue sensing remains a significant challenge.

Purpose of the Study:

  • To propose and demonstrate a mm-sized wireless biomedical sensor system for continuous glucose concentration monitoring.
  • To overcome power limitations in implantable devices for enhanced glucose sensing.
  • To enable low-power, wireless data acquisition from fluorescent hydrogel glucose sensors.

Main Methods:

  • Designed a mm-sized wireless system utilizing backscattered frequency-modulation communication.
Keywords:
WPTbatterylessfluorescentglucoseimplantablewireless

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  • Optimized reader structure for efficient wireless power transfer and data communication.
  • Integrated a fluorescent hydrogel sensor for glucose level detection within a 3x6 mm device.

    • Main Results:

    • Achieved a miniaturized implantable device size of 3x6 mm².
    • Demonstrated an operational distance of 2 mm with 33 dBm transmission power.
    • Confirmed that backscattered signal frequency correlates with fluorescent glucose sensor light intensity.

    Conclusions:

    • The developed wireless system enables low-power, continuous glucose monitoring using mm-sized implants.
    • The optimized reader design facilitates efficient wireless power and data transfer.
    • This technology holds potential for various fluorescence-based biosensors, enhancing comfort, biocompatibility, and stability.