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Recent Advances in Aptasensor for Cytokine Detection: A Review
Jinmyeong Kim1, Seungwoo Noh1, Jeong Ah Park1
1Department of Chemical Engineering, Kwangwoon University, 20 Kwangwoon-Ro, Nowon-gu, Seoul 01897, Korea.
Sensors (Basel, Switzerland)
|December 28, 2021
Summary
Monitoring cytokine secretion is crucial for medical research. This review highlights aptasensors and aptamers for sensitive cytokine detection in vivo.
Area of Science:
- Immunology
- Biochemistry
- Molecular Biology
Background:
- Cytokines are immune-modulating proteins secreted by immune cells, vital for cell signaling, replication, death, and recovery.
- Excessive cytokine secretion can lead to uncontrolled inflammation, damaging healthy cells.
- In vivo monitoring of cytokine secretion is highly valuable for medical and biological research.
Purpose of the Study:
- To review recent advancements in cytokine detection methods.
- To focus on the application of aptasensors utilizing aptamers for cytokine detection.
- To highlight the potential of aptamers as alternatives to antibodies in biosensing.
Main Methods:
- Review of recent scientific literature on cytokine detection techniques.
- Analysis of studies employing aptasensors for in vivo cytokine monitoring.
- Examination of aptamer characteristics and their utility in biosensor development.
Main Results:
- Aptasensors offer a promising approach for sensitive and specific cytokine detection.
- Aptamers demonstrate advantageous properties, including ease of production and modification.
- Recent studies show the potential of aptamer-based biosensors for in vivo applications.
Conclusions:
- Aptasensors represent a significant advancement in cytokine detection technology.
- Aptamers are versatile tools for developing novel biosensing platforms.
- Further research into aptasensor technology can enhance in vivo monitoring capabilities for various biological and medical applications.
