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Selenium-Functionalized Corn Starch as a Biodegradable GPx Mimic with High Catalytic Performance.

Shufei Jiao1, Zijie Liu1, Min Liu1

  • 1School Petroleum and Chemical Engineering, Beibu Gulf University, Qinzhou 535011, China.

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|December 28, 2021
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Summary

This study developed a novel selenium-functionalized starch (Se-starch80) for enhanced antioxidant properties. The new material exhibits high glutathione peroxidase (GPx)-like activity and offers a biodegradable platform for selenium supplementation.

Keywords:
GPxmimicOSA starchcatalytic mechanismcytotoxicityselenium functionalization

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Area of Science:

  • Biomaterials Science
  • Food Chemistry
  • Nanotechnology

Background:

  • Traditional selenium-rich foods have limitations like long cultivation times and inconsistent selenium levels.
  • Selenium-functionalized starch (Se-starch80) is a key functional food for selenium supplementation, but its traditional preparation has drawbacks.
  • Existing selenium-rich materials often lack stability and efficient antioxidant performance.

Purpose of the Study:

  • To develop a novel selenium-functionalized starch (Se-starch80) with enhanced antioxidant capabilities.
  • To investigate the structural and catalytic properties of the synthesized Se-starch80.
  • To establish a biodegradable polymer platform for high-performing glutathione peroxidase (GPx)-like mimics.

Main Methods:

  • Synthesis of Se-starch80 via nucleophilic addition of NaSeH to octenyl succinic anhydride waxy corn starch ester (OSA starch).
  • Characterization using 1HNMR, XPS, SEM-EDS, XRD, and FT-IR to confirm structure and selenium anchoring.
  • Evaluation of GPx-like catalytic activity and cytotoxicity assays.

Main Results:

  • Successful synthesis of Se-starch80 with selenium anchored onto the starch framework without significant structural damage.
  • Se-starch80 demonstrated exceptionally high GPx-like catalytic activity (initial rate = 3.64 μM/min), approximately 1.5 × 10^5 times higher than small-molecule mimics.
  • The material exhibited enzyme-like saturated kinetics and no cytotoxicity, indicating its potential as a safe and effective antioxidant agent.

Conclusions:

  • The developed Se-starch80 offers a biodegradable and highly efficient platform for selenium supplementation with superior GPx-like activity.
  • This novel functionalized starch overcomes the limitations of traditional selenium-rich foods and small-molecule mimics.
  • The study presents a promising approach for creating advanced biomaterials for antioxidant applications.