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Future developments and new research in genitourinary cancers. Perspectives.

R B Alexander, D S Coffey

    Cancer
    |August 1, 1987
    PubMed
    Summary

    Advances in genitourinary cancer therapy show promise, but metastatic disease remains a challenge. New systemic therapies, including angiogenesis factors and immunotherapy, are needed for advanced renal and prostate cancers.

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    Area of Science:

    • Oncology
    • Genitourinary Cancer Therapy
    • Systemic Therapy

    Background:

    • Significant progress has been made in treating genitourinary cancers.
    • Metastatic disease in many genitourinary tumors remains a significant clinical challenge.
    • Testicular cancer treatment has seen success due to effective systemic therapy.

    Purpose of the Study:

    • To review advances in genitourinary cancer therapy.
    • To highlight the unmet need for effective treatments for metastatic disease, particularly in renal and prostatic carcinomas.
    • To discuss novel systemic therapy approaches based on basic experimental principles.

    Main Methods:

    • Review of current literature on genitourinary cancer therapy.
    • Discussion of emerging systemic therapy modalities.
    • Exploration of potential therapeutic targets and agents.

    Main Results:

    • Effective systemic therapy has revolutionized testicular cancer treatment.
    • Effective treatments for metastatic transitional cell carcinoma are emerging.
    • Advanced renal and prostatic carcinomas currently lack effective curative therapies.

    Conclusions:

    • Novel systemic therapy approaches are crucial for addressing metastatic genitourinary cancers.
    • Potential strategies include targeting angiogenesis, and utilizing immunotherapy agents like interleukin II, lymphokine-activated killer cells, and tumor necrosis factor.

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