Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Importance of Awareness-raising for Preventing and Managing Antimicrobial Resistance: Focusing on a National Awareness Survey.

Public health weekly report·2026
Same author

Accelerating genetic diagnosis in the NICU: neonatologist-driven rapid whole genome sequencing.

Scientific reports·2026
Same author

SVO70 (Optimal Target Low-Density Lipoprotein Cholesterol Level for Small Vessel Occlusion Stroke): Rationale and Study Design.

Journal of the American Heart Association·2026
Same author

Gastrointestinal Surgery Status and the Risks of Ischemic Stroke and Safety Outcomes With Direct Oral Anticoagulants Versus Warfarin in Atrial Fibrillation: A Nationwide Population-Based Cohort Study.

Journal of stroke·2026
Same author

Viral Infection-Inspired Autonomous Detection of Fusion-Competent Viruses for Screening and Environmental Surveillance.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Distinction between acute and chronic carotid disease based on computed tomography angiography in acute ischemic stroke patients with carotid artery occlusion.

BMC neurology·2026

Related Experiment Video

Updated: Oct 8, 2025

Detection of SARS-CoV-2 Receptor-Binding Domain Antibody using a HiBiT-Based Bioreporter
07:44

Detection of SARS-CoV-2 Receptor-Binding Domain Antibody using a HiBiT-Based Bioreporter

Published on: August 12, 2021

3.3K

SARS-CoV-2 Variant Screening Using a Virus-Receptor-Based Electrical Biosensor.

Sungwook Park1, Hojun Kim1, Kyungmin Woo1

  • 1Biomaterials Research Center, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.

Nano Letters
|December 28, 2021
PubMed
Summary
This summary is machine-generated.

A new biosensor detects SARS-CoV-2 variants by targeting the ACE2 receptor, overcoming mutation challenges. This portable device offers rapid, sensitive COVID-19 screening comparable to molecular tests.

Keywords:
ACE2SARS-CoV-2biosensorvariant screeningvirus receptor

More Related Videos

Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection
10:25

Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection

Published on: June 5, 2021

4.8K
Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research
06:08

Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research

Published on: September 8, 2023

1.4K

Related Experiment Videos

Last Updated: Oct 8, 2025

Detection of SARS-CoV-2 Receptor-Binding Domain Antibody using a HiBiT-Based Bioreporter
07:44

Detection of SARS-CoV-2 Receptor-Binding Domain Antibody using a HiBiT-Based Bioreporter

Published on: August 12, 2021

3.3K
Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection
10:25

Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection

Published on: June 5, 2021

4.8K
Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research
06:08

Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research

Published on: September 8, 2023

1.4K

Area of Science:

  • Biomedical Engineering
  • Infectious Disease Diagnostics
  • Biosensor Technology

Background:

  • SARS-CoV-2 variants pose risks due to increased transmissibility, virulence, and immune evasion.
  • Current biosensors face challenges in detecting variants due to mutating viral components.
  • Angiotensin-converting enzyme 2 (ACE2) is a conserved viral receptor, making it a stable target for variant detection.

Purpose of the Study:

  • To develop a highly sensitive and portable COVID-19 screening biosensor.
  • To utilize the conserved ACE2 receptor for detecting SARS-CoV-2 variants.
  • To overcome the sensitivity limitations of existing receptor-based biosensors.

Main Methods:

  • Designed a dual-gate field-effect transistor biosensor.
  • Employed a synthetic virus for biosensor optimization, mimicking SARS-CoV-2 features.
  • Validated the biosensor's performance using clinical samples.

Main Results:

  • The biosensor achieved rapid detection of SARS-CoV-2 within 20 minutes.
  • Demonstrated high sensitivity, comparable to molecular diagnostic tests (approximately 165 copies/mL).
  • Successfully screened for SARS-CoV-2, indicating potential for variant detection.

Conclusions:

  • A virus-receptor-based biosensor using ACE2 is a viable strategy for infectious disease screening.
  • The developed biosensor offers a sensitive and portable solution for COVID-19 detection.
  • This approach holds promise for pandemic prevention through early and accurate diagnostics.