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Updated: Oct 8, 2025
Intracerebroventricular Injection of Amyloid-β Peptides in Normal Mice to Acutely Induce Alzheimer-like Cognitive Deficits
Published on: March 16, 2016
The beneficial effect of synbiotics consumption on Alzheimer's disease mouse model via reducing local and systemic
Shin-Meng Deng1, Chia-Jung Chen2, Hung-Lung Lin2
1Institute of Brain Science, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Abstract:
Alzheimer's disease (AD) is a neurodegenerative disease that impairs multiple memory domains without an effective prevention or treatment approach. Amyloid plaque-induced neuroinflammation exacerbates neurodegeneration and cognitive impairment in AD. To reduce neuroinflammation, we applied prebiotics or synbiotics to modulate the gut-brain axis in the AD mouse model. AD-like deficits were reduced in mice treated with synbiotics, suggesting that dietary modulation of the gut-brain axis is a potential approach to delay AD progression.
