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[Evolution of nutritional status, immunological and virological parameters in children with vertically transmitted

María Georgina Oberto1, Elizabeth Liliana Asis2, María Daniela Defagó3

  • 1Escuela de Nutrición de la Facultad de Ciencias Médicas de la Universidad Nacional de Córdoba. georginaoberto@hotmail.com.

Revista De La Facultad De Ciencias Medicas (Cordoba, Argentina)
|December 28, 2021
PubMed

Insights

Highly active antiretroviral treatment (HAART) in vertically transmitted HIV-infected children showed hypertriglyceridemia as a key adverse effect. Anemia was also prevalent, highlighting the need for interdisciplinary monitoring of nutritional status.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Nutritional Science

Background:

  • Continuous growth monitoring is crucial for identifying anthropometric and metabolic disorders in HIV treatment.
  • Understanding the interplay between nutritional status, immunological/virological parameters, and highly active antiretroviral treatment (HAART) is vital for vertically HIV-infected children.

Purpose of the Study:

  • To analyze the evolution of nutritional status in vertically HIV-infected children.
  • To assess the association between nutritional status, immunological and virological parameters, and HAART.
  • To identify potential adverse effects of HAART on nutritional status.

Main Methods:

  • A cohort of 56 children (0-12 years) with vertically transmitted HIV infection was studied.
  • Evaluated anthropometric, biochemical, immunological, virological, and clinical parameters over three medical controls.
  • Data analyzed by age group ( 6 years) and HAART regimens, including protease inhibitors (PIs).

Main Results:

  • Most children maintained normal BMI, but 10.71% were overweight/obese.
  • Hypertriglyceridemia was observed in 64.29% of children, particularly those on PI-containing regimens.
  • Anemia affected 51.79% of children, while clinical manifestations like pneumonia and severe immunosuppression decreased over time.

Conclusions:

  • Hypertriglyceridemia emerged as the primary medication adverse effect in this cohort.
  • The high prevalence of anemia and hypertriglyceridemia necessitates careful interdisciplinary management.
  • Long-term monitoring of nutritional and metabolic parameters is essential for optimizing HAART in children.
Abstract

Keywords:
nutritional statusanthropometrychildHIV

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