Related Experiment Video
Updated: Oct 8, 2025
07:36
Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice
Published on: June 12, 2021
6.9K
Lessons from transmissible cancers for immunotherapy and transplant
Rafael Cardoso Maciel Costa Silva1, Carolina Panis2, Bruno Ricardo Barreto Pires3
1Laboratory of Immunoreceptors and Signaling, Instituto de Biofísica Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio De Janeiro, Brazil.
Immunological Medicine
|December 28, 2021
Summary
Horizontal cancer transmission between vertebrates requires cell transfer and a suppressed immune response. Studying transmissible tumors offers insights into major histocompatibility complex (MHC) mechanisms and immune rejection, relevant to cancer and transplant biology.
Area of Science:
- Comparative oncology
- Immunology
- Transplant biology
Background:
- Horizontal cancer transmission is a rare phenomenon observed in some vertebrates.
- Successful transmission necessitates cancer cell dissemination and recipient immune tolerance.
- Transmissible cancers serve as unique models for studying immune responses and major histocompatibility complex (MHC) interactions.
Purpose of the Study:
- To explore the mechanisms of horizontal cancer transmission in vertebrates.
- To draw parallels between immune-mediated tissue rejection and transmissible cancers.
- To discuss cellular and molecular aspects of cancer immunotherapy and anti-rejection strategies.
Main Methods:
- Review of existing literature on transmissible cancers and immune responses.
- Comparative analysis of immune-mediated rejection in transplantation and cancer.
- Discussion of immunological and molecular pathways involved.
Main Results:
- Horizontal transmission depends on cancer cell transfer and host immune evasion.
- Major histocompatibility complex (MHC) plays a crucial role in both tissue rejection and transmissible cancer recognition.
- Insights from transmissible cancers can inform cancer immunotherapy and transplant rejection therapies.
Conclusions:
- Transmissible cancers provide valuable insights into immune system interactions and rejection mechanisms.
- Understanding these mechanisms can advance cancer immunotherapy and transplant tolerance strategies.
- Further research into MHC and immune evasion in transmissible cancers is warranted.
Related Concept Videos
01:27Tumor Immunotherapy
721
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
721
01:30Cancer Vaccines
548
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
548
01:40Cell-mediated Immune Responses
75.0K
Overview
75.0K
01:27Cytotoxic T Cells-mediated Immune Response
3.9K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
3.9K
01:24Tissue Transplantation
567
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
567
02:43Mouse Models of Cancer Study
5.8K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
5.8K