Related Experiment Video
Updated: Oct 8, 2025

Investigation of Spatial Interaction Between Astrocytes and Neurons in Cleared Brains
Published on: March 31, 2022
[A clear cerebrospinal fluid - but an unclear diagnosis]
Raphaël Tamò1, Elisabeth Simons1, Lars C Huber1
1Klinik Innere Medizin Standort Triemli, Department Innere Medizin, Stadtspital Zürich.
History:
A 35-year-old, previously healthy woman presented with short history of headache and fever. Several other family members reported active hand, foot, and mouth disease.
Findings:
Clinical findings showed subfebrile temperatures and a prominent meningism. Cerebrospinal fluid and computed tomography of the head were unrevealing. Subsequent PCR-analysis of the cerebrospinal fluid was positive for Enteroviral-RNA.
Diagnosis And Therapy:
Enteroviral-meningitis was diagnosed. The empirically administered antimicrobial therapy was stopped and further diagnostic tests could be withheld.
Course:
Symptom-oriented therapy resulted in complete resolution within the next few days.
Conclusions:
Our case emphasizes that, in patients with typical signs of meningeal irritation, normal cellular analysis of the cerebrospinal fluid does not exclude the presence of infectious meningitis. The astute clinician should be reminded that this constellation is highly suggestive of enteroviral meningitis.
More Related Videos
14:59Neuronavigation and Laparoscopy Guided Ventriculoperitoneal Shunt Insertion for the Treatment of Hydrocephalus
Published on: October 14, 2022
10:05Three-Dimensional Imaging of the Vertebral Lymphatic Vasculature and Drainage using iDISCO+ and Light Sheet Fluorescence Microscopy
Published on: May 22, 2020
Related Concept Videos
Cerebrospinal Fluid
CSF Production
CSF is produced mainly in the choroid plexus, a network of capillaries and ependymal cells located within the ventricular system of the brain....
Aneurysm II: Clinical Manifestations and Diagnostic Studies
Cranial and Spinal Meninges
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...
Anatomy of the Brain: Ventricles