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[Research progress on the correlation between small dense low-density lipoprotein-cholesterol and atherosclerotic

X S Fan1, L L Shen2, R Hu1

  • 1Department of Clinical Laboratory, Beijing Anzhen Hospital, Beijing 100029, China.

Zhonghua Yu Fang Yi Xue Za Zhi [Chinese Journal of Preventive Medicine]
|December 28, 2021
PubMed

Insights

Small dense low-density lipoprotein cholesterol (sdLDL-C) shows stronger atherogenic effects than traditional markers. Understanding sdLDL-C is crucial for early prevention and diagnosis of atherosclerotic cardiovascular disease (ASCVD).

Area of Science:

  • Cardiology
  • Biochemistry
  • Preventive Medicine

Background:

  • Atherosclerotic cardiovascular disease (ASCVD) is a growing clinical concern.
  • Traditional lipid parameters like low-density lipoprotein-cholesterol (LDL-C) have diagnostic limitations.
  • Small dense low-density lipoprotein cholesterol (sdLDL-C) exhibits a greater atherogenic potential.

Purpose of the Study:

  • To review detection methods for sdLDL-C.
  • To summarize research on the correlation between sdLDL-C and ASCVD risk.
  • To discuss intervention strategies and factors influencing sdLDL-C levels.

Main Methods:

  • Literature review of common sdLDL-C detection techniques.
  • Analysis of population-based studies linking sdLDL-C to ASCVD.
  • Synthesis of information on sdLDL-C modulation and influencing factors.

Main Results:

  • sdLDL-C has lower receptor affinity, longer circulation, and easier arterial penetration.
  • These properties contribute to its enhanced atherogenic effect compared to LDL-C.
  • Evidence supports sdLDL-C as a significant risk factor for ASCVD.

Conclusions:

  • sdLDL-C is a valuable biomarker for ASCVD risk assessment.
  • Clinicians need deeper understanding of sdLDL-C for early ASCVD detection and management.
  • Targeting sdLDL-C may improve prevention and diagnosis of atherosclerosis.

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